A Mussel-Inspired Antibacterial Hydrogel with High Cell Affinity, Toughness, Self-Healing, and Recycling Properties for Wound Healing
A Mussel-Inspired Antibacterial Hydrogel with High Cell Affinity, Toughness, Self-Healing, and Recycling Properties for Wound Healing
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DOI：
10.1021/acssuschemeng.0c06672
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发表时间：
2021-02-12
影响因子：
8.4
通讯作者：
Zhang, Ximu
中科院分区：
文献类型：
--
作者：
Deng, Xueyong;Huang, Bingxue;Zhang, Ximu
抗菌水凝胶由于其在伤口愈合中的广泛应用潜力而被广泛研究。然而，开发一种能够整合卓越的机械性能，细胞亲和性和抗菌性的抗菌水凝胶仍然是一个重大挑战。本文利用铝离子（Al 3+）和藻酸盐-多巴胺（Alg-DA）链与丙烯酰胺-丙烯酸（PAM）共聚物链通过配位、静电和氢键三重动态非共价相互作用交联，制备了一种具有抗菌和上级生物相容性的新型水凝胶。将长链季铵盐接枝到纳米原纤化纤维素（NFC）上，合成了阳离子化纳米原纤化纤维素（CATNFC），并将其用于抗菌水凝胶的制备。同时，以多巴胺（DA）和海藻酸钠为原料，制备了海藻酸钠修饰多巴胺（Alg-DA）。在水凝胶内，Alg-DA的儿茶酚基团提供了良好的成纤维细胞粘附到水凝胶。此外，水凝胶内的多类型交联结构呈现出优异的机械性能，自修复能力，并以无污染的方式回收。体外抑菌实验、细胞亲和性实验和伤口愈合实验表明，该水凝胶在预防细菌感染和促进伤口愈合过程中的组织再生方面具有综合性能。
Antibacterial hydrogels have been intensively studied due to their wide practical potential in wound healing. However, developing an antibacterial hydrogel that is able to integrate with exceptional mechanical properties, cell affinity, and adhesiveness will remain a major challenge. Herein, a novel hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate-dopamine (Alg-DA) chains to cross-link with the copolymer chains of acrylamide and acrylic acid (PAM) via triple dynamic noncovalent interactions, including coordination, electrostatic interaction, and hydrogen bonding. The cationized nanofibrillated cellulose (CATNFC), which was synthesized by the grafting of long-chain quaternary ammonium salts onto nanofibrillated cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine (Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both preventing bacterial infection and promoting tissue regeneration during wound healing processes.