Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer.
Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer.
复制标题
DOI：
10.1158/1078-0432.ccr-08-2660
复制
发表时间：
2009-08-01
期刊：
影响因子：
--
通讯作者：
Scher HI
中科院分区：
文献类型：
--
作者：
Knudsen KE;Scher HI
人类疾病的临床数据和模型表明，雄激素受体（AR）活性对前列腺癌的发生、生长和进展至关重要。因此，前列腺腺癌在疾病的所有阶段对AR信号传导的依赖性已被用于治疗播散性肿瘤，其中AR功能的消融是一线治疗的目标。虽然这些策略最初是有效的，但复发性肿瘤随着AR活性的恢复而出现，并且尚未确定持久的治疗方法来对抗这一阶段的疾病。对AR调节和AR活性复苏机制的新见解为开发新策略提供了肥沃的土壤，以更有效地抑制受体活性并延长向治疗失败的过渡。
Clinical data and models of human disease indicate that androgen receptor (AR) activity is essential for prostate cancer development, growth and progression. The dependence of prostatic adenocarcinoma on AR signaling at all stages of disease has thereby been exploited in the treatment of disseminated tumors, for which ablation of AR function is the goal of first line therapy. Although these strategies are initially effective, recurrent tumors arise with restored AR activity, and no durable treatment has yet been identified to combat this stage of disease. New insights into AR regulation and the mechanisms underlying resurgent AR activity have provided fertile ground for the development of novel strategies to more effectively inhibit receptor activity and prolong the transition to therapeutic failure.