Synthesis of Polycyclic Ethers by Two-Directional Double Ring-Closing Metathesis.
Synthesis of Polycyclic Ethers by Two-Directional Double Ring-Closing Metathesis.
复制标题
双向双闭环复分解合成多环醚。
作者：
J. Clark;Olivier Hamelin
含有六元环、七元环、八元环和九元环组合的跨稠合三环醚是通过双向双环-闭合复分解反应构建的(见方案)。这种含有烯烃、烯丙基醚、烯醇醚或炔基醚的前体的双环化反应为合成短链毒素和雪卡毒素提供了一种新的策略。PMB=(p-MEOC(6)H(4)CH(2))。
trans-Fused tricyclic ethers containing combinations of six-, seven-, eight-, and nine-membered rings are constructed using two-directional double ring-closing metathesis reactions (see scheme). Such double cyclizations of precursors bearing alkenes, allylic ethers, enol ethers, or alkynyl ethers offer a new strategy for the synthesis of brevetoxins and ciguatoxins. PMB=(p-MeOC(6)H(4)CH(2)).
短尾毒素A的全合成。
影响因子：
5.2
作者：
Crimmins,MichaelT;Zuccarello,JLucas;Ellis,JMichael;McDougall,PatrickJ;Haile,PamelaA;Parrish,JonathanD;Emmitte,KyleA
通讯作者：
Emmitte,KyleA