REM sleep episodes during the maintenance of wakefulness test in patients with sleep apnea syndrome and patients with narcolepsy.
REM sleep episodes during the maintenance of wakefulness test in patients with sleep apnea syndrome and patients with narcolepsy.
复制标题
睡眠呼吸暂停综合征和发作性睡病患者维持清醒测试期间的快速眼动睡眠发作。
作者：
Browman,CP;Gujavarty,KS;Sampson,MG;Mitler,MM
12 名睡眠呼吸暂停患者、12 名发作性睡病患者和 10 名对照者被给予 20 分钟的机会，在舒适地坐着的情况下保持清醒。测试时间为 10:00、12:00、14:00、16:00 和 18:00。与对照组相比，呼吸暂停和发作性睡病受试者保持清醒的能力较差。睡眠呼吸暂停患者白天平均有 1.4 次快速眼动 (REM) 发作，高峰发生时间为 14:00。发作性睡病患者也有睡眠发作的快速眼动期（平均值为 2.7），而对照组在白天测试期间没有出现快速眼动睡眠期。发作性睡病组和对照组在每次治疗期间发生快速眼动睡眠的概率有所不同。患者组之间发生 REM 的概率存在不同时间的差异。在任一患者组中，测试前一天晚上的 REM 阶段的数量与白天 REM 发作的发生无关。此外，在小睡研究中，当患者坐着与仰卧时，快速眼动睡眠开始的频率存在显着差异。维持清醒测试的睡眠潜伏期和快速眼动睡眠发作频率与受试者的年龄无关。事实证明，维持清醒测试作为诊断程序并不令人满意，但作为评估嗜睡症治疗效果的辅助程序似乎很有用。
Twelve patients with sleep apnea, 12 narcoleptic patients, and 10 controls were given 20-min opportunities to remain awake while sitting comfortably. Test sessions were administered at 10:00, 12:00, 14:00, 16:00, and 18:00. Apneic and narcoleptic subjects were less capable of maintaining wakefulness than controls. Patients with sleep apnea had an average of 1.4 daytime rapid eye movement (REM) episodes with the peak incidence at 14:00. Narcoleptics also had sleep onset REM periods (mean of 2.7), whereas none of the controls had REM episodes during the daytime testing. Narcoleptic and control groups differed in the probability of REM occurring at each session. There were time-of-day differences in the probability of REM occurring between patient groups. The amount of stage REM the night preceding testing was unrelated to the occurrence of REM episodes during the day in either patient group. In addition, there were notable differences in the frequency of sleep onset REM periods when patients were sitting as opposed to being supine during nap studies. Sleep latency and frequency of REM episodes on the maintenance of wakefulness test were independent of the subject’s age. The maintenance of wakefulness test proved unsatisfactory as a diagnostic procedure, but appeared useful as an adjunct procedure in the evaluation of treatment efficacy of hypersomnia.