Electricity and Magnetism: Insights into the brain from multimodal imaging.
Electricity and Magnetism: Insights into the brain from multimodal imaging.
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DOI：
10.1109/acssc.2009.5470165
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发表时间：
2009-11
期刊：
影响因子：
9.3
通讯作者：
Cohen MS
中科院分区：
文献类型：
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作者：
Cohen MS
神经成像仪器为我们提供了了解大脑功能的窗口，每个窗口都是模糊的，他们的视野也是有限的。同时从多个医疗模式收集数据，有可能克服任何工具单独存在的弱点。我们认为，脑电(EEG)和功能磁共振成像(FMRI)的结合提供了观察和假设检验，这是任何一种工具都不可能实现的。由于其安全性和非侵入性，EEG功能磁共振成像是研究人脑的最好的可用设备之一。这些方法是相辅相成的。脑电速度快，工作在可媲美单一单位活动的时间域内，但局部化能力差，视野有限。虽然fMRI在所有非侵入性成像方法中具有最高的空间分辨率，并且可以揭示认知任务中涉及的多个大脑活动中心，但与精神活动相比非常慢，对于研究快速进化的过程来说是一个糟糕的选择。在这里，我们提出了基于细胞生理学和能量学的脑电和功能磁共振信号之间耦合的理论模型，并认为这两种工具主要观察突触活动。我们讨论了相互干扰的技术问题，然后给出了几种大脑节律的模型，联合EEG和fMRI的观察为这些模型提供了重要的证据。
The windows into brain function given us by the instruments of neuroimaging each are murky and their view is limited. Simultaneous collection of data from multiple modalities offers the potential to overcome the weaknesses of any tool alone. We argue that the combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) offers observations – and hypothesis testing – not possible using either single instrument. Because of their safety profiles and their non-invasive natures, EEG fMRI are among the best available devices for the study of human brain. These methods are complementary. EEG is fast, operating in a time domain comparable to single unit activity, but its localizing power is poor and the field of view is limited. While fMRI has the highest spatial resolution of any noninvasive imaging method and can reveal multiple centers of brain activity implicated in cognitive tasks, it is very slow compared to mental activity and is a poor choice for studying rapidly evolving processes. Here, we address theoretical models of the coupling between EEG and fMRI signals based on cellular physiology and energetics and argue that both tools observe principally synaptic activity. We discuss the technical problems of mutual interference then present several models of brain rhythms for which the joint EEG and fMRI observations provide significant evidence.