Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells
Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells
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DOI：
10.1016/j.visres.2006.12.015
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发表时间：
2007-03-01
期刊：
影响因子：
1.8
通讯作者：
Dacey, Dennis M.
中科院分区：
文献类型：
--
作者：
Gamlin, Paul D. R.;McDougal, David H.;Dacey, Dennis M.
黑视蛋白是一种新型感光色素，最近被定位于表现出固有光敏性的视网膜神经节细胞群。在连续光照和随后的光偏移期间，已知灵长类动物表现出持续的瞳孔收缩反应，与固有感光神经节细胞的光反应非常相似。我们报告说，在行为猕猴中，在对传统感光信号进行药物阻断后，在连续光照和光偏移后，显着的瞳孔反应持续存在。这些瞳孔反应显示出独特的光谱调谐、慢动力学和持续的、黑视蛋白衍生的神经节细胞光反应的辐照度编码。我们通过使用光偏移后的持续瞳孔反应将我们的观察扩展到人类，以记录这些新型神经节细胞对人类瞳孔反应的贡献。我们的结果表明，固有感光视网膜神经节细胞的固有光响应在瞳孔光反射中发挥重要作用，并且主要负责光偏移后发生的持续瞳孔收缩。 (c) 2006 Elsevier Ltd. 保留所有权利。
Melanopsin, a novel photopigment, has recently been localized to a population of retinal ganglion cells that display inherent photosensitivity. During continuous light and following light offset, primates are known to exhibit sustained pupilloconstriction responses that resemble closely the photoresponses of intrinsically-photoreceptive ganglion cells. We report that, in the behaving macaque, following pharmacological blockade of conventional photoreceptor signals, significant pupillary responses persist during continuous light and following light offset. These pupil responses display the unique spectral tuning, slow kinetics, and irradiance coding of the sustained, melanopsin-derived ganglion cell photoresponses. We extended our observations to humans by using the sustained pupil response following light offset to document the contribution of these novel ganglion cells to human pupillary responses. Our results indicate that the intrinsic photoresponses of intrinsically-photoreceptive retinal ganglion cells play an important role in the pupillary light reflex and are primarily responsible for the sustained pupilloconstriction that occurs following light offset. (c) 2006 Elsevier Ltd. All rights reserved.