ROLE OF MESENCHYMAL-EPITHELIAL INTERACTIONS IN NORMAL AND ABNORMAL-DEVELOPMENT OF THE MAMMARY-GLAND AND PROSTATE
ROLE OF MESENCHYMAL-EPITHELIAL INTERACTIONS IN NORMAL AND ABNORMAL-DEVELOPMENT OF THE MAMMARY-GLAND AND PROSTATE
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DOI：
10.1002/1097-0142(19940801)74:3
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发表时间：
1994-08-01
期刊：
影响因子：
6.2
通讯作者：
CUNHA, GR
中科院分区：
文献类型：
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作者：
CUNHA, GR
乳腺（MG）和前列腺的发育通过间充质-上皮细胞相互作用发生。乳腺间充质在腹侧表皮中诱导上皮MG芽，其最终指定产奶能力的功能表达。乳腺导管分支由胚胎乳腺间充质诱导，出生后由乳腺脂肪垫促进。结缔组织对乳腺上皮分化的影响开始于产前，但在成年期，成年期乳腺上皮的结缔组织环境深刻地影响上皮生长、导管分支、上皮分化和成年期乳腺上皮产乳的能力。调节上皮增殖，并引起上皮雄激素受体和前列腺特异性分泌蛋白的表达。虽然前列腺的发育是由雄激素诱导的，但雄激素对上皮发育的作用是通过UGM的雄激素受体引起的。与MG一样，前列腺间质-上皮相互作用开始于胎儿期，但持续到成年期。来自各种腺体的成体上皮细胞对间质的反应性提高了癌也可能受结缔组织调节的可能性。事实上，UGM可以诱导大鼠前列腺癌（Dunning肿瘤）发生显著的分化变化，伴随着生长速率的降低和肿瘤发生的明显丧失。虽然间充质-上皮相互作用的机制仍然未知，但上皮和间质之间的交流无疑是多因素的，涉及细胞外基质、可溶性生长或分化以及血管生成。
Development of the mammary gland (MG) and prostate occurs via mesenchymal-epithelia interactions. Epithelial MG buds are induced in ventral epidermis by mammary mesenchyme, which ultimately specifies the functional expression of the ability to produce milk. Mammary ductal branching is induced by embryonic mammary mesenchyme and is promoted by the mammary fat pad postnatally. These influences of connective tissue on the differentiation of mammary epithelium (ME) begin prenatally, but in adulthood, the connective tissue environment of adult ME profoundly influences epithelial growth, ductal branching, epithelial differentiation, and the ability of adult ME to produce milk.In a similar fashion, prostatic development occurs via mesenchymal-epithelia interactions in which urogenital sinus mesenchyme (UGM) induces epithelial morphogenesis, regulates epithelial proliferation, and evokes the expression of epithelial androgen receptors and prostate-specific secretory proteins. Although prostatic development is induced by androgens, androgenic effects on epithelial development are elicited via androgen receptors of UGM. As in MG, mesenchymal-epithelial interactions in the prostate begin during fetal periods, but continue into adulthood. The responsiveness of adult epithelial cells from various glands to stroma raises the possibility that carcinomas also may be regulated by connective tissue. Indeed, UGM can induce a rat prostatic carcinoma (Dunning tumor) to undergo striking changes in differentiation, which are accompanied by a reduction in growth rate and an apparent loss of tumorigenesis. Although the mechanism of mesenchymal-epithelial interactions remains unknown, the communication between the epithelium and stroma undoubtedly is multifactorial, involving the extracellular matrix, soluble growth or differentiation, and angiogenesis.