Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells.
Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells.
复制标题
血清素系统部分参与尼罗罗非鱼免疫细胞的免疫调节。
DOI：
10.3389/fimmu.2022.944388
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
血清素（5-羟色胺）是一种众所周知的影响情绪、行为和认知的神经递质。此外，在哺乳动物中还发现了血清素的多种免疫调节功能。然而，血清素系统在鱼类免疫中的调节作用仍不清楚。在这项研究中，鉴定并表征了尼罗罗非鱼（Oreochromis niloticus）的各种血清素能标记。研究了细菌感染过程中血清素系统的参与情况。此外，还评估了尼罗罗非鱼免疫细胞内血清素能标记的表达特征和特定功能。总体而言，尼罗罗非鱼中 22 个进化保守的血清素标记基因被克隆和表征。这些分子的转录水平在大脑中最为丰富，并且它们的转录物是在无乳链球菌感染期间诱导的。然而，尼罗罗非鱼免疫细胞上几乎不存在血清素标记，并且在免疫反应过程中没有观察到明显的免疫调节作用。本研究为进一步研究鱼类免疫机制以及动物血清素系统的进化奠定了理论基础。
Serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. Additionally, numerous immunomodulatory functions of serotonin have been discovered in mammals. However, the regulatory role of the serotonin system in fish immunity remains unclear. In this study, various serotonergic markers in Nile tilapia (Oreochromis niloticus) were identified and characterized. The involvement of the serotonin system during bacterial infection was investigated. Moreover, the expression characteristics and specific functions of serotonergic markers within Nile tilapia immune cells were also assessed. Overall, 22 evolutionarily conserved serotonergic marker genes in Nile tilapia were cloned and characterized. Transcriptional levels of these molecules were most abundant in the brain, and their transcripts were induced during Streptococcus agalactiae infection. Nevertheless, few serotonergic markers exist on Nile tilapia immune cells, and no distinct immunomodulation effect was observed during an immune response. The present study lays a theoretical foundation for further investigation of the immunological mechanisms in fish as well as the evolution of the serotonin system in animals.
DOI：
10.1111/j.1538-7836.2009.03476.x
发表时间：
2009-07
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
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作者：
Duerschmied D;Canault M;Lievens D;Brill A;Cifuni SM;Bader M;Wagner DD
通讯作者：
Wagner DD