Epidemiological investigation of a Serratia liquefaciens outbreak in a neurosurgery department
Epidemiological investigation of a Serratia liquefaciens outbreak in a neurosurgery department
复制标题
DOI：
10.1016/j.jhin.2004.09.029
复制
发表时间：
2005-05-01
影响因子：
6.9
通讯作者：
Marty, N
中科院分区：
文献类型：
--
作者：
Dubouix, A;Roques, C;Marty, N
2001年2月至2003年3月期间，Rangueil大学医院（图卢兹，爆发;法国南部）神经外科的17名患者发生了产沙氏沙雷氏菌感染。由于临床分离株表现出非典型的大肠杆菌类型（即庆大霉素耐药），怀疑发生了暴发。通过脉冲场凝胶电泳进行的分子分析表明，所有患者都存在遗传联系。此外，还确定了引入流行性沙雷氏菌属菌株的患者，并表明其与暴发期间观察到的两个流行高峰有关。调查未能发现防腐剂和肥皂或所用机械消毒器中存在水库。然而，当对患者的定殖进行调查时，观察到阳性携带，可以认为这是流行菌株传播的潜在风险。由于抗生素治疗和S.因此，在选择的过程中，必须考虑选择效应。最后，在实施卫生措施的同时控制了疫情。(c)2004年，医院感染协会。由爱思唯尔有限公司出版。保留所有权利。
Between February 2001 and March 2003, 17 patients from the neurosurgery department of the University Hospital of Rangueil (Toulouse, Outbreak; Southern France) developed Serratia liquefaciens infections. Due to the atypical antibiotype displayed by the clinical isolates (i.e. gentamicin resistance), an outbreak was suspected. Molecular analysis carried out by pulsed-field get electrophoresis demonstrated a genetic link for all patients. Furthermore, the patient who introduced the epidemic Serratia strain was also identified and shown to be related to the two epidemic peaks observed during the outbreak period. Investigation failed to reveal a reservoir among the antiseptics and soaps, or among the mechanical ventilators used. However, when the colonization of patients was investigated, positive carriage was observed and could be considered as a potential risk for the spread of the epidemic strain. Due to the delay between antibiotherapy and S. liquefaciens colonization, a selection effect had to be considered. Finally, implementation of hygiene measures was accompanied by control of the outbreak. (c) 2004 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.