Boolean Biomaterials: Logic‐Based Delivery of Site‐Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials (Adv. Mater. 33/2019)
Boolean Biomaterials: Logic‐Based Delivery of Site‐Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials (Adv. Mater. 33/2019)
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DOI：
10.1002/adma.201970237
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发表时间：
2019-08
影响因子：
29.4
通讯作者：
Prathamesh Milind Gawade;Jared A. Shadish;Barry A. Badeau;Cole A. DeForest
中科院分区：
文献类型：
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作者：
Prathamesh Milind Gawade;Jared A. Shadish;Barry A. Badeau;Cole A. DeForest
术语“两性离子聚合物”是指在其重复单元中具有一对相反电荷基团的聚合物。当这些带相反电荷的基团在分子水平上均匀分布时，分子通过离子溶剂化表现出整体的中性电荷，具有很强的水化效应。这种强烈的水化作用是两性离子材料一系列特殊性能的基础，包括抵抗蛋白质吸附、界面润滑、促进蛋白质稳定性、在溶液中抗冻等。因此，两性离子材料近年来在生物医学和工程上的应用受到了广泛的关注。本文综述了两性离子材料的基本原理、水化和无污垢行为、不同类型的两性离子表面和聚合物及其在生物医学上的应用。
The term “zwitterionic polymers” refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these oppositely charged groups are equally distributed at the molecular level, the molecules exhibit an overall neutral charge with a strong hydration effect via ionic solvation. The strong hydration effect constitutes the foundation of a series of exceptional properties of zwitterionic materials, including resistance to protein adsorption, lubrication at interfaces, promotion of protein stabilities, antifreezing in solutions, etc. As a result, zwitterionic materials have drawn great attention in biomedical and engineering applications in recent years. In this review, we give a comprehensive and panoramic overview of zwitterionic materials, covering the fundamentals of hydration and nonfouling behaviors, different types of zwitterionic surfaces and polymers, and their biomedical applications.