Community exposure to perfluorooctanoate: Relationships between serum levels and certain health parameters
Community exposure to perfluorooctanoate: Relationships between serum levels and certain health parameters
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DOI：
10.1097/01.jom.0000233380.13087.37
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发表时间：
2006-08-01
影响因子：
3.2
通讯作者：
Shaw, Leslie Michael
中科院分区：
文献类型：
--
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
目的：本研究的目的是确定某些毒性生物标志物和/或肝脏或甲状腺疾病的既往诊断是否与长期环境暴露于全氟辛酸酯（PFOA）的社区中的血清PFOA浓度相关。研究方法：血清（PFOA），血液学和生化生物标志物，并进行问卷调查，以分层随机抽样和志愿者之间的抽签选择371名居民。中位PFOA为181-571 ng/mL）。结果如下：血清（PFOA）与肝功能或肾功能检查、胆固醇、促甲状腺激素或与红细胞指数、白色细胞或血小板计数之间无354 ng/mL（四分位距）显著正相关。在有肝脏或甲状腺疾病史的患者中，平均血清（PFOA）没有增加。结论：使用测量的终点证明PFOA没有毒性;其他终点需要解决。
Objective: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA. Methods: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 181-571 ng/mL). Results: No 354 ng/mL (interquartile range significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease. Conclusions: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.