Hypogyrification in obsessive-compulsive disorder
Hypogyrification in obsessive-compulsive disorder
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DOI：
10.1017/s0033291716003202
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发表时间：
2017-04-01
影响因子：
6.9
通讯作者：
Koch, K.
中科院分区：
文献类型：
--
作者：
Rus, O. G.;Reess, T. J.;Koch, K.
背景先前的研究假设神经发育危险因素可能在强迫症（OCD）的发病机制中发挥作用。皮质折叠已被证明是正常和改变神经发育的可靠指标，但在强迫症中，迄今为止几乎没有研究。本研究调查是否在脑回的改变是可检测的强迫症，如果是这样，这些是如何与临床特征。我们比较了75名强迫症患者和75名匹配的健康受试者的全脑局部回旋指数（lGI）。此外，对于患者中表现出改变的lGI的那些区域，我们探讨了与症状严重程度、发病年龄和药物影响的潜在关系。强迫症患者有一个显着降低lGI在右顶叶，中央前，但也有颞叶，pars triangularis和喙中额区相比，健康受试者。发现与发病年龄呈正相关，但与症状严重程度无关。共病或药物治疗均无影响。在强迫症中发现的脑回化减少证实了以前在其他精神疾病中的发现，并表明改变可能已经发生在大脑发育的早期阶段。我们的研究结果支持这样的想法，改变皮质折叠可能代表的一个特点的障碍，虽然纵向研究需要澄清的轨迹，这在强迫症的形态测量。
Background. Previous studies hypothesized that neurodevelopmental risk factors may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Cortical folding has been shown to be a reliable indicator for normal and altered neurodevelopment, but in OCD it has barely been investigated up to now. The present study investigates whether alterations in gyrification are detectable in OCD and, if so, how these are associated with clinical characteristics.Method. We compared the local Gyrification Index (lGI) between 75 OCD patients and 75 matched healthy subjects across the whole brain. In addition, for those regions exhibiting an altered lGI in patients we explored a potential relationship to symptom severity, age of onset, and influence of medication.Results. OCD patients had a significantly decreased lGI in right parietal, precentral but also insula, temporal, pars triangularis and rostral middle frontal regions compared to healthy subjects. A positive association with age of onset was found but no association with symptom severity. There was no effect of co-morbidity or medication.Conclusions. The reduced gyrification found in OCD confirms previous findings in other psychiatric disorders and suggests that alterations may already occur during early stages of brain development. Our findings support the idea that altered cortical folding might represent a trait characteristic of the disorder although longitudinal studies are needed to clarify the trajectory of this morphological measure in OCD.