Cell therapy for autoimmune diseases.
Cell therapy for autoimmune diseases.
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DOI：
10.1186/ar2128
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发表时间：
2007
影响因子：
4.9
通讯作者：
Tyndall A
中科院分区：
文献类型：
--
作者：
Dazzi F;van Laar JM;Cope A;Tyndall A
细胞疗法以骨髓移植的形式率先用于治疗恶性肿瘤，随后在自身免疫性疾病中进行了测试并成功应用。自体造血干细胞移植（HSCT）已经成为治疗预后非常差的疾病的一种选择，如严重的硬皮病、多发性硬化症和狼疮，在这些疾病中，靶向治疗几乎没有效果。调理方案的改进几乎消除了移植相关的死亡率，因此使造血干细胞移植成为一种相对安全的选择。尽管HSCT仍然是一种非特异性的方法，但在这一领域获得的知识已经导致了新途径的确定。事实上，很明显，造血干细胞移植的治疗效果不能仅仅是高剂量免疫抑制的结果，而是自身免疫条件下异常免疫调节重置的结果。专业和非专业免疫抑制细胞的鉴定及其生物学特性对其临床应用产生了巨大的兴趣。调节性T细胞，在一些自身免疫性疾病中发现异常，被认为是实现长期缓解的核心。来自骨髓的间充质干细胞最近被证明不仅能够分化成多种组织，而且还能发挥强大的抗增殖作用，从而抑制免疫反应，延长造血干细胞的存活时间。所有这些潜在的资源显然需要在临床前水平进行研究，但支持自身免疫性疾病细胞治疗的极大热情。
Cell therapy, pioneered for the treatment of malignancies in the form of bone marrow transplantation, has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem cell transplantation (HSCT) has become a curative option for conditions with very poor prognosis such as severe forms of scleroderma, multiple sclerosis, and lupus, in which targeted therapies have little or no effect. The refinement of the conditioning regimens has virtually eliminated transplant-related mortality, thus making HSCT a relatively safe choice. Although HSCT remains a nonspecific approach, the knowledge gained in this field has led to the identification of new avenues. In fact, it has become evident that the therapeutic efficacy of HSCT cannot merely be the consequence of a high-dose immuno-suppression, but rather the result of a resetting of the abnormal immune regulation underlying autoimmune conditions. The identification of professional and nonprofessional immunosuppressive cells and their biological properties is generating a huge interest for their clinical exploitation. Regulatory T cells, found abnormal in several autoimmune diseases, have been proposed as central to achieve long-term remissions. Mesenchymal stem cells of bone marrow origin have more recently been shown not only to be able to differentiate into multiple tissues, but also to exert a potent antiproliferative effect that results in the inhibition of immune responses and prolonged survival of haemopoietic stem cells. All of these potential resources clearly need to be investigated at the preclinical level but support a great deal of enthusiasm for cell therapy of autoimmune diseases.
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DOI：
10.1084/jem.20021387
发表时间：
2003-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barthlott T;Kassiotis G;Stockinger B
通讯作者：
Stockinger B
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
27.4
作者：
de Kleer, IM;Brinkman, DMC;Wulffraat, NM
通讯作者：
Wulffraat, NM
影响因子：
158.5
作者：
Edwards, JCW;Szczepanski, L;Shaw, T
通讯作者：
Shaw, T
影响因子：
--
作者：
Burt, RK;Oyama, Y;Barr, WG
通讯作者：
Barr, WG