Infectious Etiologies of Acute Febrile Illness among Patients Seeking Health Care in South-Central Cambodia
Infectious Etiologies of Acute Febrile Illness among Patients Seeking Health Care in South-Central Cambodia
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DOI：
10.4269/ajtmh.2012.11-0409
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发表时间：
2012-02-01
影响因子：
3.3
通讯作者：
Putnam, Shannon D.
中科院分区：
文献类型：
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作者：
Kasper, Matthew R.;Blair, Patrick J.;Putnam, Shannon D.
人类发热性疾病的病原体可能因地区和国家而异，这表明诊断、治疗和控制方案需要基于对地区特异性病因学的系统评价。2006年12月至2009年12月，柬埔寨中南部9个保健诊所的9 997名急性发热患者参加了一项研究，以阐明病因。入组后，采集呼吸道标本、全血和血清。对病毒、细菌和寄生虫病原体进行了检测。在38.0%的患者中确定了病因。流感是最常见的病原体，其次是登革热、疟疾和从血培养中分离出的细菌病原体。此外，3.5%的入组患者感染了一种以上的病原体。我们的数据提供了第一个系统的评估急性发热性疾病在柬埔寨中南部的病因。基于症状的监测研究的数据可以帮助指导发展中国家的公共卫生应对措施。
The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations.