Mitochondrial dynamics and viral infections: A close nexus.
Mitochondrial dynamics and viral infections: A close nexus.
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DOI：
10.1016/j.bbamcr.2014.12.040
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Siddiqui A
中科院分区：
文献类型：
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作者：
Khan M;Syed GH;Kim SJ;Siddiqui A
病毒操纵细胞机器和功能来破坏有利于病毒增殖的细胞内环境。它们战略性地改变多任务线粒体的功能，以影响能量产生、新陈代谢、生存和免疫信号传导。线粒体要么以单个细胞器的异质群体的形式出现，要么以大型互连的管状网络的形式出现。线粒体网络非常容易受到生理和环境损伤（包括病毒感染）的影响，并通过线粒体裂变和融合动态维持。线粒体动力学与线粒体选择性自噬“线粒体自噬”相结合，协调线粒体质量控制和稳态。线粒体动力学影响细胞稳态、新陈代谢和先天免疫信号传导，因此可能是病毒感染结果的主要决定因素。在此，我们回顾了病毒感染期间线粒体动力学如何受到影响，以及这种复杂的相互作用如何有益于病毒感染过程和相关疾病。本文是题为“Mitophagy”的特刊的一部分。线粒体动力学影响线粒体和细胞功能。病毒感染期间线粒体动力学受到影响。病毒利用线粒体动力学和线粒体自噬来促进感染过程。病毒改变的线粒体动力学决定了感染的结果。线粒体动力学的破坏会促进病毒的发病机制。
Viruses manipulate cellular machinery and functions to subvert intracellular environment conducive for viral proliferation. They strategically alter functions of the multitasking mitochondria to influence energy production, metabolism, survival, and immune signaling. Mitochondria either occur as heterogeneous population of individual organelles or large interconnected tubular network. The mitochondrial network is highly susceptible to physiological and environmental insults, including viral infections, and is dynamically maintained by mitochondrial fission and fusion. Mitochondrial dynamics in tandem with mitochondria-selective autophagy ‘mitophagy’ coordinates mitochondrial quality control and homeostasis. Mitochondrial dynamics impacts cellular homeostasis, metabolism, and innate-immune signaling, and thus can be major determinant of the outcome of viral infections. Herein, we review how mitochondrial dynamics is affected during viral infections and how this complex interplay benefits the viral infectious process and associated diseases. This article is part of a Special Issue entitled: Mitophagy. Mitochondrial dynamics influences mitochondrial and cellular functions. Mitochondrial dynamics is affected during viral infections. Viruses exploit mitochondrial dynamics and mitophagy to benefit infectious process. Virus-altered mitochondrial dynamics determines the outcome of infection. Disruption of mitochondrial dynamics promotes viral pathogenesis.