Play, but not observing play, engages rat medial prefrontal cortex
Play, but not observing play, engages rat medial prefrontal cortex
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DOI：
10.1111/ejn.14908
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发表时间：
2020-07-31
影响因子：
3.4
通讯作者：
Sanguinetti-Scheck, Juan, I
中科院分区：
文献类型：
--
作者：
Concha-Miranda, Miguel;Hartmann, Konstantin;Sanguinetti-Scheck, Juan, I
老鼠在玩捉迷藏游戏时有复杂的认知能力。玩捉迷藏游戏强烈地涉及到内侧前额叶皮质，前额叶皮质神经元的活动反映了游戏的结构。我们想知道前额叶神经元是否也会反映与游戏相关的神经活动。具体地说，我们问的是，当动物自己玩耍和观察别人玩耍时，大鼠内侧前额皮质的活动有何不同。与我们之前的工作一致，当动物玩自己时，我们观察到内侧前额叶皮质的活动，这一活动与游戏事件密切相关。然而，观察游戏并没有导致大鼠内侧前额叶皮质的类似激活。观察游戏时的射击率低于真实游戏时的射击率。在玩捉迷藏时，游戏事件对内侧前额叶皮质反应的调制作用较强，而在观察捉迷藏时，对内侧前额叶皮质反应的调制作用较弱。我们得出结论，在我们的实验条件下，大鼠的前额叶皮质不能反映游戏事件。
Rats have elaborate cognitive capacities for playing Hide & Seek. Playing Hide & Seek strongly engages medial prefrontal cortex and the activity of prefrontal cortex neurons reflects the structure of the game. We wondered if prefrontal neurons would also show a mirroring of play-related neural activity. Specifically, we asked how does the activity in the rat medial prefrontal cortex differ when the animal plays itself versus when it observes others playing. Consistent with our previous work, when the animal plays itself we observed medial prefrontal cortex activity that was sharply locked to game events. Observing play, however, did not lead to a comparable activation of rat medial prefrontal cortex. Firing rates during observing play were lower than during real play. The modulation of responses in medial prefrontal cortex by game events was strong during playing Hide & Seek, but weak during observing Hide & Seek. We conclude the rat prefrontal cortex does not mirror play events under our experimental conditions.