Acute helminth infection enhances early macrophage mediated control of mycobacterial infection
Acute helminth infection enhances early macrophage mediated control of mycobacterial infection
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DOI：
10.1038/mi.2012.131
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发表时间：
2013-09-01
影响因子：
8
通讯作者：
Walzl, G.
中科院分区：
文献类型：
--
作者：
du Plessis, N.;Kleynhans, L.;Walzl, G.
分枝杆菌和蠕虫的共同感染在发展中国家很普遍，但这如何改变宿主对每种病原体的免疫控制尚未得到全面了解。在这项研究中，我们证明，急性日本圆线虫（Nb）鼠感染减少早期肺分枝杆菌定植。肺结核分枝杆菌集落形成单位的这种Nb相关减少与肺CD4 T细胞的早期活化和活化增加以及辅助性T细胞1型（Th1）和Th2细胞因子分泌增加有关。在合并感染动物中也观察到中性粒细胞和肺泡巨噬细胞（AM）的加速和短暂增加。AM显示经典和替代激活的标记。从Nb感染后5天的供体小鼠获得的肺巨噬细胞的鼻内转移显着降低受体小鼠的肺牛分枝杆菌卡介苗清除率。这些数据表明，早期Nb感染激发巨噬细胞应答，这在随后的分枝杆菌感染的早期阶段是保护性的。
Co-infection with mycobacteria and helminths is widespread in developing countries, but how this alters host immunological control of each pathogen is not comprehensively understood. In this study, we demonstrate that acute Nippostrongylus brasiliensis (Nb) murine infection reduce early pulmonary mycobacterial colonization. This Nb-associated reduction in pulmonary Mycobacterium tuberculosis colony-forming units was associated with early and increased activation of pulmonary CD4 T cells and increased T helper type 1 (Th1) and Th2 cytokine secretion. An accelerated and transient augmentation of neutrophils and alveolar macrophages (AMs) was also observed in co-infected animals. AMs displayed markers of both classical and alternative activation. Intranasal transfer of pulmonary macrophages obtained from donor mice 5 days after Nb infection significantly reduced pulmonary Mycobacterium bovis Bacille Calmette-Guerin clearance in recipient mice. These data demonstrate that early stage Nb infection elicits a macrophage response, which is protective during the early stages of subsequent mycobacterial infection.