Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom.
Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom.
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DOI：
10.1117/1.jbo.23.3.030504
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发表时间：
2018-03
影响因子：
3.5
通讯作者：
Pogue BW
中科院分区：
文献类型：
--
作者：
Ahmed SR;Jia JM;Bruza P;Vinogradov S;Jiang S;Gladstone DJ;Jarvis LA;Pogue BW
放射治疗在组织中产生切伦科夫光发射，这种光可用于激活分子探针。使用腋窝淋巴结区域的几何形状检查了从人体模型内感测组织分子氧传感器发光的可行性。磷光传感器 PtG4 的总量接近 1 纳摩尔，可以以亚毫米空间分辨率检测深度达 30 毫米的区域。落射照明几何结构中的辐射片扫描提供了最佳覆盖范围，最大强度投影图像提供了这一概念的说明。这项工作提供了尝试此类体内成像所需的初步信息。
Radiation therapy produces Cherenkov optical emission in tissue, and this light can be utilized to activate molecular probes. The feasibility of sensing luminescence from a tissue molecular oxygen sensor from within a human body phantom was examined using the geometry of the axillary lymph node region. Detection of regions down to 30-mm deep was feasible with submillimeter spatial resolution with the total quantity of the phosphorescent sensor PtG4 near 1 nanomole. Radiation sheet scanning in an epi-illumination geometry provided optimal coverage, and maximum intensity projection images provided illustration of the concept. This work provides the preliminary information needed to attempt this type of imaging in vivo.