Global Estimate of Lung Cancer Mortality Attributable to Residential Radon
Global Estimate of Lung Cancer Mortality Attributable to Residential Radon
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DOI：
10.1289/ehp2503
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发表时间：
2018-05-01
影响因子：
10.4
通讯作者：
Krewksi, Daniel
中科院分区：
文献类型：
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作者：
Gaskin, Janet;Coyle, Doug;Krewksi, Daniel
背景：氡是导致肺癌的第二大原因，世界卫生组织在2010年将其列为第五大致死原因。66个国家氡暴露的最新数据库使人们能够估计氡造成的肺癌死亡率的全球负担。目的：我们的目标是估计2012年全球居民氡所致肺癌死亡率的人口归因负担。方法：使用归因分数法确定氡引起肺癌死亡率的人群归因风险（PAR），使用三种氡引起肺癌的过度相对风险模型。结果：在66个进行有代表性的全国氡调查的国家中，2012年住宅氡导致肺癌死亡率的中位PAR估计值是一致的，暴露年龄-浓度（EAC）模型（BEIR VI）、Hunter模型和Kreuzer模型分别为16.5%、14.4%和13.6%。使用EAC模型的平均PAR范围从日本的4.2% （95% CI: 0.9, 11.7）到亚美尼亚的29.3% (95% CI: 22.9, 35.7)， 66个国家的中位数为16.5%。2012年，所有66个国家氡导致的肺癌死亡总数为226,057人，占癌症死亡总数的中位数为3.0%。结论：用于估计氡导致肺癌的过量相对风险的三种模型之间，以及归因分数方法和生命表分析之间的一致发现，证实了居住氡是造成肺癌死亡率的很大一部分原因
BACKGROUND: Radon is the second most important cause of lung cancer, ranked by the World Health Organization as the fifth leading cause of mortality in 2010. An updated database of national radon exposures for 66 countries allows the global burden of lung cancer mortality attributable to radon to be estimated.OBJECTIVE: Our goal was to estimate the global population attributable burden of lung cancer mortality in 2012 from residential radon.METHODS: Estimates of the population attributable risk (PAR) of lung cancer mortality from radon were determined using the attributable fraction approach, using three models for excess relative risk of lung cancer from radon.RESULTS: The estimates of the median PAR of lung cancer mortality from residential radon in 2012 for the 66 countries having representative national radon surveys were consistent, as 16.5%, 14.4%, and 13.6% for the exposure-age-concentration (EAC) model (BEIR VI), the Hunter model, and the Kreuzer model, respectively. The mean PAR using the EAC model ranged from 4.2% (95% CI: 0.9, 11.7) for Japan, to 29.3% (95% CI: 22.9, 35.7) for Armenia, with a median for the 66 countries of 16.5%. Radon-attributable lung cancer deaths for all 66 countries totaled 226,057 in 2012 and represent a median of 3.0% of total cancer deaths.CONCLUSIONS: Consistent findings between the three models used to estimate excess relative risks of lung cancer from radon, and between the attributable fraction methodology and the life table analysis, confirm that residential radon is responsible for a substantial proportion of lung cancer mortality