THE MUTATIONAL MELTDOWN IN ASEXUAL POPULATIONS
THE MUTATIONAL MELTDOWN IN ASEXUAL POPULATIONS
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DOI：
10.1093/oxfordjournals.jhered.a111354
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发表时间：
1993-09-01
影响因子：
3.1
通讯作者：
GABRIEL, W
中科院分区：
文献类型：
--
作者：
LYNCH, M;BURGER, R;GABRIEL, W
由于有害突变的积累而导致的适应性丧失在小的专性无性群体中似乎是不可避免的，因为这些群体不能通过重组或回复突变来重建高度适应的基因型。这种突变的累积预计会导致种群规模的最终减少，这有利于未来突变的偶然积累。这种群体规模减少和突变积累之间的协同作用导致了一个被称为突变崩溃的灭绝过程，并为专性无性恋的罕见性提供了一个强有力的解释。我们给出了一个概述的突变崩溃的理论，展示了这个过程如何取决于人口的人口统计特性，突变的属性，以及健身和突变数量之间的关系。
Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these ate incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutations. This synergistic interaction between population size reduction and mutation accumulation leads to an extinction process known as the mutational meltdown, and provides a powerful explanation for the rarity of obligate asexuality. We give an overview of the theory of the mutational meltdown, showing how the process depends on the demographic properties of a population, the properties of mutations, and the relationship between fitness and number of mutations incurred.