MicroPET: A high resolution PET scanner for imaging small animals
MicroPET: A high resolution PET scanner for imaging small animals
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DOI：
10.1109/23.596981
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发表时间：
1997-06-01
影响因子：
1.8
通讯作者：
Phelps, ME
中科院分区：
文献类型：
--
作者：
Cherry, SR;Shao, Y;Phelps, ME
MicroPET是一种高分辨率正电子发射断层扫描(PET)扫描仪，专为小型实验室动物成像而设计。它由30个位置灵敏闪烁探测器组成，每个探测器都有一个8x8的小晶体阵列，通过光纤耦合到一个多通道光电倍增管上。探测器的本征分辨率平均为1.68 mm，能量分辨率在15%~25%之间，在511keV的时间分辨率为2.4 ns。MicroPET探测器环直径为17.2 cm，成像视场为112 mm×18 mm。该扫描仪没有隔板，只在3D模式下运行。距离扫描仪中心1厘米的重建图像分辨率为2.0 mm，并且几乎各向同性，体积分辨率为8 mm(3)。相比之下，最先进的临床PET系统的体积分辨率在50-75 mm(3)的范围内。已经获得并报告了幽灵的初始图像。一种电脑控制的床正在建设中，它将结合一个小摆动来改进空间采样。预计这将进一步提高空间分辨率。MicroPET是第一台采用新型闪烁体LSO的PET扫描仪，据我们所知，它是目前存在的分辨率最高的多环PET扫描仪。
MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 position-sensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm(3). For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mm(3). Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.