Chronic Renal Insufficiency Cohort Study (CRIC): Overview and Summary of Selected Findings
Chronic Renal Insufficiency Cohort Study (CRIC): Overview and Summary of Selected Findings
复制标题
DOI：
10.2215/cjn.04260415
复制
发表时间：
2015-11-01
影响因子：
9.8
通讯作者：
Feldman, Harold I.
中科院分区：
文献类型：
--
作者：
Denker, Matthew;Boyle, Suzanne;Feldman, Harold I.
慢性肾功能不全队列（CRIC）研究是美国一项针对不同种族和民族的CKD患者的多中心前瞻性研究。尽管该研究的最初目的是确定CKD进展的新预测因素，并阐明近4000名CKD患者心血管疾病的风险和表现，但CRIC研究已发展成为调查广泛的CKD相关主题的国家资源。这项研究已经发表了9090篇科学论文，促进了许多年轻的肾脏病研究事业，并促进了国际合作，重点是了解慢性肾病的全球负担。CRIC研究的第三阶段将于2015年完成1500名额外的研究参与者的入组，旨在回答有关轻中度CKD发病率和死亡率的问题，并评估老年人CKD的负担。本综述强调了CRIC研究在种族和民族、CKD进展、CKD和认知以及心血管疾病结局方面的一些显著发现；它还概述了全球肾脏病学界正在进行的和即将到来的机会，通过这项研究加强对CKD及其相关并发症的理解。
The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrum of CKD-related topics. The study has produced >90 published scientific articles, promoted many young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.