DIFFERENCES IN THE CLINICAL MANIFESTATIONS OF SICCA SYNDROME IN THE PRESENCE AND ABSENCE OF RHEUMATOID-ARTHRITIS
DIFFERENCES IN THE CLINICAL MANIFESTATIONS OF SICCA SYNDROME IN THE PRESENCE AND ABSENCE OF RHEUMATOID-ARTHRITIS
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DOI：
10.1016/0002-9343(79)91110-0
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发表时间：
1979-01-01
影响因子：
5.9
通讯作者：
DECKER, JL
中科院分区：
文献类型：
--
作者：
MOUTSOPOULOS, HM;WEBBER, BL;DECKER, JL
回顾了存在和不存在类风湿性关节炎的干燥综合征患者的临床特征。所有患者在诊断为干燥综合征后均在美国国立卫生研究院接受了至少 5 年的随访。患者（22）仅患有干燥综合征； 21名患者患有明确的类风湿性关节炎和干燥综合征。类风湿性关节炎往往先于干燥综合征的发生。两组诊断干燥综合征的平均年龄相同。血清免疫球蛋白、补体第三成分（C3）、类风湿因子滴度和唾液组织病理学没有发现显着差异。临床特征非常明显。仅患有干燥综合征的患者复发性腮腺炎的频率明显更高。雷诺现象、紫癜、淋巴结肿大、肌炎和肾脏受累。这两组的临床特征加上已知的血清学和遗传差异表明干燥综合征本身就是一个独特的病理实体。
The clinical features of patients with the sicca syndrome in the presence and absence of rheumatoid arthritis were reviewed. All patients were followed at the National Institutes of Health for at least 5 yr after the diagnosis of sicca syndrome. Patients (22) had sicca syndrome alone; 21 patients had definite rehumatoid arthritis and the sicca syndrome. Rheumatoid arthritis tended to precede the development of sicca syndrome. The mean age at diagnosis of sicca syndrome was the same in both groups. No significant differences in serum immunoglobulin, the 3rd component of complement (C3), rheumatoid factor titer and salivary histopathology were found. The clinical features were quite distinct. Patients with sicca syndrome alone had a significantly greater frequency of recurrent parotitis. Raynaud''s phenomenon, purpura, lymphadenopathy, myositis and renal involvement. The clinical characteristics of these 2 groups coupled with the known serologic and genetic differences suggested that sicca syndrome alone is a distinct pathologic entity.