Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis.
Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis.
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DOI：
10.18632/oncotarget.10676
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发表时间：
2016-08-16
期刊：
影响因子：
--
通讯作者：
Hsu CL
中科院分区：
文献类型：
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作者：
Wang HM;Lin TL;Kuo YC;Li HP;Chang KP;Lin CY;Fan HC;Lin AC;Hsieh CH;Tsang NM;Lee LY;Chan SC;Lui KW;Chang YS;Hsu CL
不同器官转移的鼻咽癌（NPC）的总生存率差异已被证明。在这里，我们试图通过评估血浆和肿瘤组织标志物与患者生存率的关系来确定潜在的机制。对178例鼻咽癌转移患者治疗前血浆EB病毒DNA浓度、细胞因子、组织巨噬细胞、增殖和凋亡标志物进行了检测。中位总生存期（OS）为19个月。单器官转移患者的结局优于多器官转移患者（中位OS：26个月vs. 16个月），具有统计学意义。在单器官转移病例中，肺转移患者的生存期仅长于骨转移或肝转移患者（中位OS：50个月vs.21个月vs.18个月; P <0.001）。单器官转移组中，肺转移组治疗前血浆EBVDNA浓度低于骨转移组和肝转移组。血浆干扰素-γ-诱导蛋白-10（IP-10）和单核细胞趋化蛋白-1（MCP-1）的表达水平与单个器官转移灶的OS和EBV DNA载量相关。肝转移组巨噬细胞浸润密度和增殖指数均高于肺转移组。治疗前血浆EBV DNA载量低、细胞因子如IP-10和MCP-1的表达、组织巨噬细胞浸润和增殖指数可能导致总生存期的差异。
Differential overall survival of nasopharyngeal carcinoma (NPC) with different organ site metastases has been documented. Here, we attempted to determine the underlying mechanisms by assessing plasma and tumor tissue markers in relation to patient survival. Pretreatment plasma Epstein-Barr virus (EBV) DNA concentrations, cytokines and tissue macrophages, proliferation and apoptosis markers were determined in 178 patients with metastatic NPC. The median overall survival (OS) was 19 months. Patients with single organ metastases had better outcomes than those with multiple organ metastases (median OS: 26 months vs. 16 months), with statistical significance. Among the single organ involvement cases, patients with lung metastasis only showed longer survival than those with bone or liver involvement (median OS: 50 months vs. 21 months vs. 18 months; P < 0.001). Pretreatment plasma EBV DNA concentrations were lower in patients with lung metastasis than bone or liver metastasis among single organ site groups. Plasma interferon-γ-inducible protein-10 (IP-10) and monocyte chemotactic protein-1 (MCP-1) expression levels were correlated with differential single organ site metastasis OS and EBV DNA load. Liver metastatic tissue had higher density of infiltrating macrophages and proliferative index than the lung metastatic group. Low pretreatment plasma EBV DNA load, expression of cytokines, such as IP-10 and MCP-1, tissue macrophage infiltration, and proliferative index may contribute to the differences in overall survival.