Dental amalgam affects urinary selenium excretion
Dental amalgam affects urinary selenium excretion
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DOI：
10.1385/bter:85:2:137
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发表时间：
2002-02-01
影响因子：
3.9
通讯作者：
Isrenn, R
中科院分区：
文献类型：
--
作者：
Hol, PJ;Vamnes, JS;Isrenn, R
硒可能对汞中毒有保护作用。本研究的目的是调查使用银汞合金充填者的尿硒排泄是否受到影响。这项研究的原因是，牙科汞齐是普通人群中无机汞暴露的最重要来源，尽管这种暴露的潜在毒性仍然是争论的主题。通过静脉注射螯合剂2，3-二碳丙烷-1-磺酸(DMPS)(2 mg/kg)来刺激金属排泄。随后在24小时内每隔一段时间收集尿样。用氢化物发生原子吸收光谱法测定硒的含量。这项研究包括20名声称患有牙科银汞合金症状的人和21名使用汞合金填充物的健康人。有两个对照组没有银汞合金。其中一组因担心汞释放引起的疾病而更换了银汞合金(n=20)，而另一组从未使用过银汞合金(n=19)。在24小时内，使用银汞合金的个体排出的硒(中位数为36.4mug)比不使用银汞合金的个体(47.5mug)少(p=0.016)。有银汞相关症状组(42.4杯)和无银汞相关症状组(39.4杯)之间的硒排泄量没有差异(p=0.15)。结果表明，接触低水平汞的牙科汞齐患者尿中的硒排泄量低于未接触者。
Selenium may have a protective effect against mercury toxicity. The aim of the present study was to investigate if selenium excretion in urine was affected in persons with dental amalgam fillings. The reason for this study is that dental amalgam is the most important source of inorganic mercury exposure in the general population, although the potential toxic effects of this exposure remain a subject for debate.The chelating agent 2,3 dimercaptopropane-1-sulfonate (DMPS) was injected intravenously (2 mg/kg) to provoke metal excretion. Urine samples were subsequently collected at intervals over a 24-h period. Selenium concentration was determined by hydride-generation atomic absorption spectrometry. The study was comprised of 20 persons who claimed symptoms from dental amalgam and 21 healthy persons with amalgam fillings. There were two control groups without amalgam. One control group had amalgam replaced because of concern about illness resulting from mercury release (n = 20), whereas the other control group never had amalgam (n = 19).Individuals with amalgam excreted less selenium (36.4 mug, median value) over 24 hours than those without amalgam (47.5 mug) (p = 0.016). There was no difference in selenium excretion between groups with (42.4 mug) and without (39.4 mug) amalgam-related symptoms (p = 0.15).The findings indicate that individuals exposed to low levels of elemental mercury from dental amalgam excrete less selenium to urine than unexposed individuals.