Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography.
Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography.
复制标题
使用高分辨率外周定量计算机断层扫描对类风湿性关节炎的掌骨和桡骨进行定量表征。
DOI：
10.1111/1756-185x.12558
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发表时间：
2017
影响因子：
2.5
通讯作者：
Li,Xiaojuan
中科院分区：
文献类型：
--
作者：
Yang,Haitao;Yu,Andrew;Burghardt,AndrewJ;Virayavanich,Warapat;Link,ThomasM;Imboden,JohnB;Li,Xiaojuan
目的本研究的目的是：（i）开发一种使用高分辨率外周定量计算机断层扫描（HR-pQCT）定量类风湿关节炎（RA）患者手部和手腕骨骨的骨矿物质密度（BMD）和微结构的标准化方法;（ii）比较RA和绝经后骨质减少（PM-OP）受试者的定量骨参数;和（iii）相关的定量骨参数在桡骨远端的掌骨头在RA subjects.MethodsHR‐pQCT成像的优势手和手腕进行了12例女性RA患者。计算RA患者和健康对照组第二和第三掌骨2-12%头部区域的BMD和骨小梁参数，并进行比较。骨参数也计算为110片的桡骨远端RA患者和对照组和PM‐OP妇女从以前的study.ResultsCompared数据相比，对照组，RA患者有显着降低BMD，骨小梁体积和数量，并增加骨小梁的异质性在第三掌骨和桡骨远端。RA组骨小梁数目明显少于骨量减少组，外环骨小梁BMD与内环骨小梁BMD比值明显高于骨量减少组（P<0.05）。RA患者第三掌骨和桡骨远端骨小梁BMD显著相关（ρ = 0.918，P <0.0001）。结论本研究建立了一种使用HR-pQCT定量RA患者手部和腕部骨骨密度和骨小梁特性的标准化方法。RA患者的骨结构恶化与骨质减少妇女的骨结构恶化相似，并且发现受影响关节附近的骨小梁丢失与远离关节的骨丢失相关。
AimThe objectives of this study were: (i) to develop a standardized method of quantifying bone mineral density (BMD) and microarchitecture in the hand and wrist bones of patients with rheumatoid arthritis (RA) using high resolution‐ peripheral quantitative computed tomography (HR‐pQCT); (ii) to compare quantitative bone parameters between RA and post‐menopausal osteopenic (PM‐OP) subjects; and (iii) to correlate quantitative bone parameters at the distal radius with those at the metacarpal heads in RA subjects.MethodsHR‐pQCT imaging of the dominant hand and wrist was performed in 12 female RA patients. BMD and trabecular parameters for the 2–12% head region of the second and third metacarpals were calculated and compared between RA patients and healthy controls. Bone parameters were also calculated for 110 slices of the distal radius in RA patients and compared to data from controls and PM‐OP women from a previous study.ResultsCompared to controls, RA patients had significantly decreased BMD, trabecular volume and number, and increased trabecular heterogeneity in the third metacarpal and distal radius. Significantly lower trabecular number and significantly higher ratio of outer annular trabecular BMD to inner trabecular BMD were observed in patients with RA, compared to patients with osteopenia (P<0.05). Trabecular BMD in the third metacarpal and in the distal radius were significantly correlated (ρ = 0.918,P<0.0001) in RA patients.ConclusionThis study established a standardized method for quantifying bone density and trabecular properties in the hand and wrist bones of RA patients using HR‐pQCT. Deterioration of bone structure in RA patients was found comparable to that in osteopenic women, and trabecular bone loss near affected joints was found to be correlated with bone loss away from joints.