Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.
Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.
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他莫昔芬在 ACI.COP-Ept2 大鼠模型中诱导雌二醇诱导的乳腺癌消退。
DOI：
10.1007/s10549-008-0169-0
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发表时间：
2009
影响因子：
3.8
通讯作者：
Sauter,EdwardR
中科院分区：
文献类型：
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作者：
Ruhlen,RachelL;Willbrand,DanaM;Besch-Williford,CynthiaL;Ma,Lixin;Shull,JamesD;Sauter,EdwardR
ACI大鼠是一种独特的人类乳腺癌模型，其乳腺癌是由雌激素诱导的，无需致癌物、辐射、异种移植或转基因操作。我们试图描述 ACI 大鼠同源变异体 ACI.COP-Ept2 的乳腺癌特征。所有植入雌二醇的老鼠都会在 5-7 个月内患上乳腺癌。用他莫昔芬治疗患有雌二醇诱发乳腺癌的大鼠三周。通过磁共振成像测量，他莫昔芬使肿瘤质量减少了 89%。肿瘤表达雌激素受体 (ER)、孕激素受体 (PR) 和 Erbb2。与邻近的非肿瘤乳腺相比，ERα 和 PR 在肿瘤中过度表达。因此，该模型与激素反应性人类乳腺癌高度相关。
The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5–7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ERα and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.