Pax6: A multi-level regulator of ocular development
Pax6: A multi-level regulator of ocular development
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DOI：
10.1016/j.preteyeres.2012.04.002
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发表时间：
2012-09-01
影响因子：
17.8
通讯作者：
Ashery-Padan, Ruth
中科院分区：
文献类型：
--
作者：
Shaham, Ohad;Menuchin, Yotam;Ashery-Padan, Ruth
眼发育是器官发生研究的一个范例，从上皮组织形态发生诱导透镜到神经元的特化和分化。转录因子Pax6已被证明在这些过程中发挥关键作用。Pax6是启动发育途径，上皮组织的图案，组织特异性基因的激活和与其他调控途径的相互作用所必需的。在这里，我们研究了过去几十年来积累的数据，从广泛的生化模块和基因操作的Pax6基因的分析。具体而言，我们描述了Pax6的表达模式，蛋白质的DNA结合特性，其特定的作用和作用机制在透镜和视网膜发育的各个阶段的调节。Pax6在多个水平上发挥功能，整合细胞外信息并执行细胞内在分化程序，最终导致不同眼部谱系的特化抗分化。(C)2012爱思唯尔有限公司保留所有权利。
Eye development has been a paradigm for the study of organogenesis, from the demonstration of lens induction through epithelial tissue morphogenesis, to neuronal specification and differentiation. The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific genes and interaction with other regulatory pathways. Herein we examine the data accumulated over the last few decades from extensive analyses of biochemical modules and genetic manipulation of the Pax6 gene. Specifically, we describe the regulation of Pax6's expression pattern, the protein's DNA-binding properties, and its specific roles and mechanisms of action at all stages of lens and retinal development. Pax6 functions at multiple levels to integrate extracellular information and execute cell-intrinsic differentiation programs that culminate in the specification anti differentiation of a distinct ocular lineage. (C) 2012 Elsevier Ltd. All rights reserved.