Prognostic Value of Immunoscore and PD-L1 Expression in Metastatic Colorectal Cancer Patients with Different RAS Status after Palliative Operation.
Prognostic Value of Immunoscore and PD-L1 Expression in Metastatic Colorectal Cancer Patients with Different RAS Status after Palliative Operation.
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不同RAS状态转移性结直肠癌姑息手术后免疫评分和PD-L1表达的预后价值
DOI：
10.1155/2018/5920608
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发表时间：
2018
影响因子：
--
通讯作者：
Liu T
中科院分区：
文献类型：
--
作者：
Liu R;Peng K;Yu Y;Liang L;Xu X;Li W;Yu S;Liu T
结直肠癌（CRC）是中国第五大癌症死亡原因，也是第五大最常见的癌症。大约25%的CRC在诊断时处于晚期，40%的CRC患者进展为转移性结直肠癌（mCRC）。RAS突变状态现在通常用于选择治疗。但RAS突变状态是否是一个预后指标仍是一个问题。本研究检测了60例中国原发性结直肠癌姑息性手术患者的RAS突变、免疫评分（IS）和PD-L1表达。Kaplan-Meier生存分析显示RAS野生型患者的总生存期（OS）优于RAS突变型患者。此外，在多变量分析中，RAS突变和PD-L1表达被证明是OS的独立负预后因素（P = 0.044，HR：0.258，和95%CI：0.069-0.967; P = 0.048，HR：0.276，和95%CI：0.077- 0，988）。提示PD-L1表达和RAS状态联合IS可能是mCRC姑息性手术的预后指标。
Colorectal cancer (CRC) is the fifth leading cause of cancer death and the fifth most commonly diagnosed cancer in China. Approximately, 25% of CRC was in the advanced stage as diagnosed, and 40% of patients with CRC progress to metastatic colorectal cancer (mCRC). RAS mutation status is now routinely used to select their therapy. But it is still a question whether RAS mutation status is a prognostic marker. In our study, we detected RAS mutation, immunoscore (IS), and PD-L1 expression in 60 Chinese mCRC patients who received palliative operation. The Kaplan-Meier survival analysis showed that the overall survival (OS) in patients with RAS wild type was better than those with RAS mutated type. Moreover, in multivariate analysis, RAS mutation and PD-L1 expression were demonstrated to be the independent negative prognostic factors for OS (P = 0.044, HR: 0.258, and 95% CI: 0.069–0.967; P = 0.048, HR: 0.276, and 95% CI: 0.077–0,988). All results suggested that, combined with IS, PD-L1 expression and RAS status may be the prognostic indicators for mCRC patients with palliative operation.
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影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
影响因子：
10.1
作者：
Gabrielson A;Wu Y;Wang H;Jiang J;Kallakury B;Gatalica Z;Reddy S;Kleiner D;Fishbein T;Johnson L;Island E;Satoskar R;Banovac F;Jha R;Kachhela J;Feng P;Zhang T;Tesfaye A;Prins P;Loffredo C;Marshall J;Weiner L;Atkins M;He AR
通讯作者：
He AR
黑色素瘤肿瘤微环境中PD-L1，IDO和T（REGS）的上调由CD8（+）T细胞驱动。
影响因子：
17.1
作者：
Spranger S;Spaapen RM;Zha Y;Williams J;Meng Y;Ha TT;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
7.3
作者：
Galon, Jerome;Mlecnik, Bernhard;Bindea, Gabriela;Angell, Helen K.;Berger, Anne;Lagorce, Christine;Lugli, Alessandro;Zlobec, Inti;Hartmann, Arndt;Bifulco, Carlo;Nagtegaal, Iris D.;Palmqvist, Richard;Masucci, Giuseppe V.;Botti, Gerardo;Tatangelo, Fabiana;Delrio, Paolo;Maio, Michele;Laghi, Luigi;Grizzi, Fabio;Asslaber, Martin;D'Arrigo, Corrado;Vidal-Vanaclocha, Fernando;Zavadova, Eva;Chouchane, Lotfi;Ohashi, Pamela S.;Hafezi-Bakhtiari, Sara;Wouters, Bradly G.;Roehrl, Michael;Nguyen, Linh;Kawakami, Yutaka;Hazama, Shoichi;Okuno, Kiyotaka;Ogino, Shuji;Gibbs, Peter;Waring, Paul;Sato, Noriyuki;Torigoe, Toshihiko;Itoh, Kyogo;Patel, Prabhu S.;Shukla, Shilin N.;Wang, Yili;Kopetz, Scott;Sinicrope, Frank A.;Scripcariu, Viorel;Ascierto, Paolo A.;Marincola, Francesco M.;Fox, Bernard A.;Pages, Franck
通讯作者：
Pages, Franck