A role for exocytosis in the spatial regulation of actin organization.
A role for exocytosis in the spatial regulation of actin organization.
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DOI：
10.1100/tsw.2003.119
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发表时间：
2003-12-18
影响因子：
--
通讯作者：
Albert S
中科院分区：
文献类型：
--
作者：
Gao XD;Albert S
肌动蛋白细胞骨架的有效组织对于许多细胞功能是重要的。然而，在细胞中局部肌动蛋白组织是如何调节的还不清楚。通过使用酵母突变体缺陷的肌动蛋白组织和分泌，我们证明了胞吐作用在肌动蛋白组织的空间调节中发挥作用。我们的研究结果表明，肌动蛋白细胞骨架，胞吐作用，也许内吞作用，可能相互依赖的效率和相互加强。
The efficient organization of the actin cytoskeleton is important for many cellular functions. However, how the local actin organization is regulated in a cell is not well understood. By using yeast mutants defective in actin organization and secretion, we demonstrated that exocytosis plays a role in the spatial regulation of actin organization. Our findings suggest that the actin cytoskeleton, exocytosis, and perhaps endocytosis, may depend on each other for efficiency and reinforce each other.