HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data
HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data
复制标题
DOI：
10.1089/aid.2015.0089
复制
发表时间：
2015-10-01
影响因子：
1.5
通讯作者：
Eron, Joseph J.
中科院分区：
文献类型：
--
作者：
Dennis, Ann M.;Hue, Stephane;Eron, Joseph J.
在北卡罗来纳州 (NC) 的艾滋病毒感染病例中，拉丁美洲人所占的比例越来越大。了解移民如何参与当地艾滋病毒传播对于指导干预措施非常重要。我们使用系统发育学来描述拉丁裔参与当地艾滋病毒传播链的特征。通过使用来自北卡罗来纳州接受护理的 177 名拉丁裔和 1,496 名非拉丁裔的 HIV pol 序列构建的最大似然系统发育，确定了传播簇。涉及一个或多个拉丁裔的高度支持的集群被描述为特征。迁移数据是通过访谈和图表审查获得的。使用对数二项式回归确定与聚类成员资格相关的因素。大多数拉丁美洲人是男性 (76%)、移民 (83%) 和 HIV-1B 感染者 (99%)。与美国出生的拉丁裔相比，移民更有可能报告异性恋风险（67% vs. 23%）（p < 0.01）。我们确定了 32 个聚类，其中包括一名或多名拉丁裔；其中涉及 53 名拉丁裔 (30%) 和 41 名非拉丁裔。移民和美国出生的拉美裔人聚集在一起的可能性相同，但移民更有可能与另一个拉美裔人聚集在一起（78% vs. 29%；p = 0.02）。按种族划分的集群组成和风险行为因集群规模而异；较大的集群包含较少的移民和较多的男男性行为者（MSM）。与当地传播集群中的移民成员资格相关的因素包括年龄
Latinos represent a growing proportion of HIV cases in North Carolina (NC). Understanding how immigrants are involved in local HIV transmission is important to guide interventions. We used phylogenetics to characterize Latino involvement in local HIV transmission chains. Transmission clusters were identified from maximum-likelihood phylogenies constructed with HIV pol sequences from 177 Latinos and 1,496 non-Latinos receiving care in NC. Highly supported clusters involving one or more Latinos were characterized. Migration data were obtained from interviews and chart review. Factors associated with cluster membership were identified using log-binomial regression. Most Latinos were male (76%), immigrants (83%), and had HIV-1B (99%). Immigrants were more likely to report heterosexual risk (67% vs. 23%) than U.S.-born Latinos (p < 0.01). We identified 32 clusters that included one or more Latinos; these involved 53 Latinos (30%) and 41 non-Latinos. Immigrant and U.S.-born Latinos were equally likely to be in clusters, but immigrants were more likely to be in clusters with another Latino (78% vs. 29%; p = 0.02). Cluster composition by ethnicity and risk behavior varied by cluster size; larger clusters contained fewer immigrants and more men who have sex with men (MSM). Factors associated with immigrant membership in local transmission clusters included age