Regulation of calcium currents by chemokines and their receptors
Regulation of calcium currents by chemokines and their receptors
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DOI：
10.1016/s0165-5728(01)00485-4
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发表时间：
2002-02-01
影响因子：
3.3
通讯作者：
Miller, RJ
中科院分区：
文献类型：
--
作者：
Oh, SB;Endoh, T;Miller, RJ
我们研究了趋化因子受体在异源表达系统和神经元中对电压依赖性Ca ~（2+）电流的调节作用。Fractalkine、SDF-1 α、RANTES和MDC分别抑制表达CX 3CR_1、CXCR_4、CCR_5和CCR_4的GlAl细胞中的I-Ba。表明它是由Gi/Go介导的。某些趋化因子还抑制背根神经节和最后区/孤束核神经元亚群中的I-Ba。这些数据提供了证据表明，趋化因子调用可能通过抑制神经元Ca 2+电流来调节神经元信号传导。(C)2002 Elsevier Science B.V保留所有权利。
We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons, Fractalkine, SDF-lalpha, RANTES and MDC inhibited the I-Ba in CX3CR1-, CXCR4-, CCR5- and CCR4-exprcssing GlAl cells, respectively, The 113, inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylinaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the I-Ba in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines call potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents. (C) 2002 Elsevier Science B.V All rights reserved.