COMPARISON OF LIVER HISTOLOGY WITH ULTRASONOGRAPHY IN ASSESSING DIFFUSE PARENCHYMAL LIVER-DISEASE
COMPARISON OF LIVER HISTOLOGY WITH ULTRASONOGRAPHY IN ASSESSING DIFFUSE PARENCHYMAL LIVER-DISEASE
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DOI：
10.1016/s0009-9260(05)80350-2
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发表时间：
1991-01-01
影响因子：
2.6
通讯作者：
MAXWELL, JD
中科院分区：
文献类型：
--
作者：
JOSEPH, AEA;SAVERYMUTTU, SH;MAXWELL, JD
为了确定超声检查评估弥漫性实质性肝病的准确性，我们对50例患有各种肝病的患者进行了一项前瞻性组织学对比研究。 在超声检查后24小时内进行肝活检，超声检查由一名不了解患者临床详情的操作员进行。 对组织学进行盲法审查，脂肪变性程度分级为轻度、中度或重度，而门静脉纤维组织增加分级为轻度、中度或已建立的肝硬化。 36例患者有脂肪变性，31例患者组织学上纤维组织增加。 超声检查正确识别了32/36例（89%）患者的脂肪变性，包括所有重度患者。 24/31例（77%）正确识别了纤维组织增加，中度纤维化和肝硬化患者的敏感性为100%。 脂肪变性的特异性为93%，纤维组织增加的特异性为89%。 这些结果表明，超声检查可以提供一个非侵入性的预测肝脏组织学，在中度和重度脂肪变性和先进的纤维化可以是高度敏感和特异性。
To establish the accuracy of ultrasonography in assessing diffuse parenchymal liver disease we performed a prospective comparative study with histology in 50 patients with a wide range of liver disease. Liver biopsy was performed within 24 h of the ultrasound examination and ultrasonography was performed by a single operator who was unaware of clinical details of the patients. Histology was reviewed blind and the degree of steatosis graded mild, moderate or severe while increased portal fibrous tissue was graded mild, moderate or established cirrhosis. Thirty-six patients had steatosis and 31 patients had increased fibrous tissue on histology. Ultrasonography correctly identified steatosis in 32/36 (89%) patients including all patients with the severe grade. Increased fibrous tissue was correctly identified in 24/31 (77%) with a sensitivity of 100% in patients with moderate fibrosis and established cirrhosis. Specificity was 93% for steatosis and 89% for increased fibrous tissue. These results show that ultrasonography can provide a non-invasive prediction of liver histology which in moderate and severe steatosis and advanced fibrosis can be both highly sensitive and specific.