Toll-like receptors in the pathogenesis of human disease
Toll-like receptors in the pathogenesis of human disease
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DOI：
10.1038/ni1116
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发表时间：
2004-10-01
影响因子：
30.5
通讯作者：
Schwartz, DA
中科院分区：
文献类型：
--
作者：
Cook, DN;Pisetsky, DS;Schwartz, DA
Toll样受体（TLR）家族成员是先天性和适应性免疫应答的关键调节因子。通过比较在参与TLR信号传导的基因中具有不同多态性的人群中的疾病发生率，研究了TLR在各种人类疾病中的功能。这些研究表明TLR功能影响多种疾病，包括败血症、免疫缺陷、动脉粥样硬化和哮喘。随着这些数据的增长，它将为疾病的发病机制提供新的见解，并为各种治疗方案的优点提供有价值的信息。
Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.