Hematology and clinical chemistry values of normal and euthymic hairless adult male Dunkin-Hartley guinea pigs (Cavia porcellus)
Hematology and clinical chemistry values of normal and euthymic hairless adult male Dunkin-Hartley guinea pigs (Cavia porcellus)
复制标题
DOI：
10.1111/j.1939-165x.1996.tb00971.x
复制
发表时间：
1996-01-01
影响因子：
1.2
通讯作者：
Bogin, Eitan
中科院分区：
文献类型：
--
作者：
Waner, Trevor;Avidar, Yaakov;Bogin, Eitan
对12只雄性Dunkin-Hartley无毛豚鼠CrI：IAF（HA）BR和10只有毛Dunkin-Hartley雄性豚鼠Crl：（HA）BR的血液标本进行血液学和血清化学测量。与有毛品系相比，在无毛豚鼠中观察到丙氨酸氨基转移酶、天冬氨酸氨基转移酶、淀粉酶和肌酸激酶的活性显著更高。无毛豚鼠的碱性磷酸酶活性较低。发现无毛豚鼠的血清尿素浓度比正常豚鼠品系高约46%。发现无毛品系的红细胞平均体积较小，血红蛋白含量较高，与有毛豚鼠相比，无毛豚鼠的白细胞减少约40%，淋巴细胞：中性粒细胞比率相反，而有毛豚鼠的淋巴细胞计数要高得多。
Hematology and serum chemistry measurements were performed on blood specimens from 12 male Dunkin-Hartley hairless guinea pigs CrI:IAF(HA)BR and 10 haired Dunkin-Hartley male guinea pigs Crl:(HA)BR. Significantly higher activities of alanine aminotransferase, aspartate aminotransferase, amylase, and creatine kinase were observed in the hairless guinea pigs as compared to the haired strain. Alkaline phosphatase activity was found to be lower in the hairless guinea pig. The hairless guinea pigs were found to have serum urea concentrations approximately 46% higher than the normal guinea pig strain. The erythrocytic mean cell volume of the hairless strain was found to be smaller, with a greater hemoglobin content Hairless guinea pigs were found to have approximately 40% fewer leukocytes with a reversed lymphocyte:neutrophil ratio compared to the haired guinea pigs which had much higher lymphocyte counts.