Studies on the morphogenesis of adenomatous polyps in the human colon
Studies on the morphogenesis of adenomatous polyps in the human colon
复制标题
人结肠腺瘤性息肉形态发生的研究
作者：
J. W. Cole;A. McKalen
人的胃肠道T道上皮是人体内最具活力的细胞群之一。它在直肠中每4至6天更新一次3，在小肠和直肠中的更新速度更快。2在正常情况下，这种细胞更新过程处于所谓的平衡状态，其中新细胞形成的速率等于细胞损失的速率。最近对人类3和动物11 *5的研究清楚地表明，新细胞几乎完全在Lieberkiihn隐窝的基部形成，然后沿着隐窝壁迁移到上皮表面，在那里，它们可能被挤出到肠腔中。目前，关于肿瘤形成过程中必须发生的正常平衡的任何改变或肿瘤生长如何改变细胞形成和迁移的正常顺序，我们知之甚少。这一报告的病人与家族性息肉病的结肠！通过组织放射自显影术的研究试图至少部分地回答这些问题。静脉内给药后，放射性（氚化）胸苷迅速掺入合成脱氧核糖核酸（DNA）的上皮细胞的细胞核中，为进行有丝分裂做准备。这使得通过组织放射自显影术在肠上皮内识别和定位这些细胞成为可能。
HE EPITHELIUM OF THE GASTROINTESTINAL T tract of man is one of the most dynamic cell populations in the body. It is renewed every 4 to 6 days in the rectum3 and at a still faster rate in the small intestine and duodenum.2 Under normal circumstances, this cell renewal process is in a state of so-called equilibrium, wherein the rate clf new cell formation is equivalent to the rate of cell loss. Recent studies in both man3 and anima11*5 have clearly shown that new cells are formed almost exclusively at the base of the crypts of Lieberkiihn and then migrate along the crypt wall to the surface of the epithelium, where, presumably, they are extruded into the lumen of the bowel. At present, very little is known regarding any alterations in the normal equilibrium that must occur in the course of tumor formation or how the normal sequence of cell formation and migration is modified by neoplastic growth. This report of a patient with familial polyposis of the colon !itudied by means of tissue autoradiography attempts to answer these questions, at least partially. Following its intravenous administration, radioactive (tritiated) thymidine is rapidly incorporated into the nuclei of epithelial cells that are synthesizing deoxyribonucleic acid ( D N A ) ~ preparatory to undergoing mitotic division. This makes possible the identification and localization of these cells within the intestinal epithelium by means of tissue autoradiographs.