ATTEMPTS TO ESTABLISH INFECTIONS WITH STRONGYLOIDES-STERCORALIS IN MICE AND OTHER LABORATORY-ANIMALS
ATTEMPTS TO ESTABLISH INFECTIONS WITH STRONGYLOIDES-STERCORALIS IN MICE AND OTHER LABORATORY-ANIMALS
复制标题
DOI：
10.1017/s0022149x00034957
复制
发表时间：
1982-01-01
影响因子：
1.6
通讯作者：
GROVE, DI
中科院分区：
文献类型：
--
作者：
DAWKINS, HJS;GROVE, DI
狗感染粪圆线虫丝状幼虫导致持续感染。家兔、豚鼠、大鼠以及11个近交系和1个远交系小鼠均未发现明显感染。对已知影响小鼠鼠链球菌感染的因素的控制，例如宿主的年龄和性别以及幼虫的出现途径，并没有促进粪便中出现杆状幼虫。给兔子、豚鼠和 C57B1/6 小鼠施用免疫抑制剂量的皮质类固醇不会导致完全发育。 T 细胞缺陷型低胸腺 (nu/nu) 小鼠的感染过程没有改变。确定了将丝状幼虫涂在小鼠皮肤上的命运；据观察，丝状幼虫在感染后几天内从皮肤经肺部迁移到肌肉。尽管粪圆线虫不会在小鼠小肠中发育成熟，但该系统确实允许体内研究驱虫药对丝状幼虫的作用以及对该寄生虫的免疫反应的许多方面。
Infection of a dog with S. stercoralis filariform larvae resulted in a persistent infection. Patent infections were not seen in rabbits, guinea pigs, rats and 11 inbred strains and 1 outbred strain of mice. Manipulation of factors known to influence S. ratti infections in mice, such as age and sex of the host and the route of larval presentation, did not facilitate the appearance of rhabditiform larvae in the stools. Administration of immunosuppressive doses of corticosteroids to rabbits, guinea pigs and C57B1/6 mice did not permit complete development. The course of infection was not altered in T cell-deficient hypothymic (nu/nu) mice. The fate of filariform larvae applied to the skin of mice was ascertained; filariform larvae were observed to migrtate from the skin via the lungs to the muscles within several days of infection. Although S. stercoralis does not develop to maturity in the small intestine of mice, this system does allow in vivo studies of the actions of anthelmintics against filariform larvae as well as a number of aspects of the immune response to this parasite.