Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
复制标题
编码蛋白酶 3（韦格纳肉芽肿自身抗原）的基因定位于人类染色体带 19p13.3。
DOI：
10.1159/000133555
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
LeBeau,MM
中科院分区：
文献类型：
--
作者：
Sturrock,AB;Espinosa3rd,R;Hoidal,JR;LeBeau,MM
Proteinase-3 (PR3) is a polymorphonuclear leukocyte serine proteinase that is a potent inducer of emphysema in experimental models. PR3 is also the target antigen associated with Wegener’s granulomatosis. By analysis of a panel of somatic cell hybrids, the gene encoding PR3 was localized previously to chromosome 19; we have used fluorescence in situ hybridization to sublocalize this gene to 19p13.3.
