HUMAN C-MYC ONC GENE IS LOCATED ON THE REGION OF CHROMOSOME-8 THAT IS TRANSLOCATED IN BURKITT-LYMPHOMA CELLS
HUMAN C-MYC ONC GENE IS LOCATED ON THE REGION OF CHROMOSOME-8 THAT IS TRANSLOCATED IN BURKITT-LYMPHOMA CELLS
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DOI：
10.1073/pnas.79.24.7824
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
CROCE, CM
中科院分区：
文献类型：
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作者：
DALLAFAVERA, R;BREGNI, M;CROCE, CM
与禽髓细胞瘤病毒(MC29)转化基因(v-myc)相关的人类序列至少由1个基因和几个可能代表假基因的相关序列代表。通过使用针对完整基因(c-myc)的DNA探针，采用Southern blotting技术对具有不同数目的人类染色体的不同体细胞杂交进行了分析。结果表明，人c-myc基因位于8号染色体上。对啮齿动物细胞和人Burkitt淋巴瘤细胞的杂交分析表明，人c-myc基因定位在924.fwdarw区域，这种细胞在8号和14号染色体之间存在相互易位。在Burkitt淋巴瘤细胞中，这个染色体区域被转移到人的2号、14号或22号染色体上。
Human sequences related to the transforming gene (v-myc) of avian myelocytomatosis virus (MC29) are represented by at least 1 gene and several related sequences that may represent pseudogenes. By using a DNA probe that is specific for the complete gene (c-myc), different somatic cell hybrids possessing varying numbers of human chromosomes were analyzed by the Southern blotting technique. The results indicate that the human c-myc gene is located on chromosome 8. The analysis of hybrids between rodent cells and human Burkitt lymphoma cells, which carry a reciprocal translocation between chromosomes 8 and 14, allowed the mapping of the human c-myc gene on region (924 .fwdarw. qtr) of chromosome 8. This chromosomal region is translocated to either human chromosome 2, 14 or 22 in Burkitt lymphoma cells.