Diffusion-weighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease -: A clinical-anatomic correlation
Diffusion-weighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease -: A clinical-anatomic correlation
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DOI：
10.1001/archneur.56.8.951
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发表时间：
1999-08-01
影响因子：
--
通讯作者：
Adair, JC
中科院分区：
文献类型：
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作者：
Na, DL;Suh, CK;Adair, JC
背景资料：克雅氏病（Creutzfeldt-Jakob disease，CJD）是一种罕见的传染性疾病，通常会导致快速进行性痴呆，并在不到1年的时间内导致死亡。虽然一些轶事报道表明弥散加权磁共振成像可能有助于证实CJD的死前诊断，但放射学数据与临床、电生理和代谢参数之间的详细相关性尚不可用。连续3例疑似CJD患者的弥散加权像信号异常与心理测量学特征、脑电图结果、结果：弥散加权像上的病灶与临床表现密切相关，而常规磁共振成像上的病灶不明显。扩散加权像上异常信号的地形分布与正电子发射和单光子发射计算机断层扫描上的异常代谢或灌注相对应。在2例中，扩散异常的偏侧性与周期性的尖波活动脑电图。结论：这些研究结果扩展了以前的观察，提出了诊断和定位效用的扩散加权成像在克雅氏病。
Background: Creutzfeldt-Jakob disease (CJD) is a rare transmissible disease that typically causes a rapidly progressive dementia and leads to death in less than 1 year. Although a few anecdotal reports suggest that diffusion-weighted magnetic resonance imaging may help substantiate premortem diagnosis of CJD, detailed correlation between radiographic data and clinical, electrophysiologic, and metabolic parameters is not available.Methods: Signal abnormalities on diffusion-weighted images in 3 consecutive patients with probable CJD were correlated with psychometric features, electroencephalographic findings, and functional images with either positron emission tomography or single photon emission computed tomography.Results: Focality of abnormalities on diffusion-weighted image, not apparent on routine magnetic resonance images, correlated closely with clinical manifestations of CJD. The topographic distribution of signal abnormality on diffusion-weighted image corresponded with abnormal metabolism or perfusion on positron emission and single photon emission computed tomographic scans. In 2 cases, the laterality of diffusion abnormalities correlated with periodic sharp wave activity on electroencephalograms.Conclusion: These findings extend previous observations that suggested a diagnostic and localizing utility of diffusion-weighted imaging in CJD.