New therapeutic key for cystic fibrosis: a role for lipoxins
New therapeutic key for cystic fibrosis: a role for lipoxins
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DOI：
10.1038/ni0404-357
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发表时间：
2004-04
影响因子：
30.5
通讯作者：
D. Takai;T. Nagase;Takao Shimizu
中科院分区：
文献类型：
--
作者：
D. Takai;T. Nagase;Takao Shimizu
囊性纤维化的特征之一是患者易发生铜绿假单胞菌肺部感染，最终损害肺功能。新的数据表明，CFTR的丢失会损害脂氧素的产生，从而阻止肺部炎症的消退，并创造一个易受进一步感染的环境。
One of the hallmarks of cystic fibrosis is the propensity of patients to develop lung infections withPseudomonas aeruginosa, which eventually compromises lung function. New data suggest loss of CFTR impairs lipoxin production, thus preventing resolution of lung inflammation and creating an environment susceptible to further infection.