Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
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血液中可检测到的 2019-nCoV 病毒 RNA 是进一步临床严重程度的有力指标
DOI：
10.1080/22221751.2020.1732837
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发表时间：
2020-01-01
影响因子：
13.2
通讯作者：
Tang, Xiaoping
中科院分区：
文献类型：
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作者：
Chen, Weilie;Lan, Yun;Tang, Xiaoping
摘要新型冠状病毒（2019-nCoV）感染引起肺炎。我们回顾性分析了临床实验室中通过实时PCR检测咽拭子、血液和肛门拭子中的病毒存在。出乎意料的是，2109-nCoV RNA很容易在血液（57例患者中的6例）和肛门拭子（28例患者中的11例）中检测到。重要的是，血液队列中所有6例可检测到病毒RNA的患者均进展至重度症状阶段，表明血清病毒RNA与疾病严重程度具有强相关性（p值= 0.0001）。11例患者中8例为重症患者。然而，肛门拭子中的病毒RNA浓度（Ct值= 24 + 39）高于患者2血液中的病毒RNA浓度（Ct值= 34 + 39），表明病毒可能在消化道中复制。总之，我们的结果证实了肺外部位存在病毒RNA。
ABSTRACT The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.