Frequent TLE1 Expression in Cutaneous Neoplasms
Frequent TLE1 Expression in Cutaneous Neoplasms
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DOI：
10.1097/dad.0000000000001186
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发表时间：
2019-01-01
影响因子：
1.1
通讯作者：
Cornejo, Kristine M.
中科院分区：
文献类型：
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作者：
Xiong, Yiqin;Dresser, Karen;Cornejo, Kristine M.
TLE 1免疫组化被广泛用作滑膜肉瘤的生物标志物。最近，我们发现TLE 1在黑色素瘤的一个子集中表达，并注意到在皮脂腺和滤泡上皮中的染色。TLE 1免疫组化尚未在皮肤肿瘤中得到很好的研究。目的是研究TLE 1在皮脂腺肿瘤、基底细胞癌（BCC）和鳞状细胞癌（SCC）中的表达，以确定染色模式是否有助于这些肿瘤的诊断或分类。对26例皮脂腺腺瘤、10例皮脂瘤、19例皮脂腺癌、20例基底细胞癌和19例鳞状细胞癌进行TLE 1免疫组化染色。阳性定义为深棕色核染色，并分级为3+（在4x下>50%的细胞的强染色）、2+（在4x下10-50%的细胞的中度染色或在10 x下>50%的细胞染色）和1+（在10 x下>50%的细胞的弱染色）。
TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. The aim was to investigate TLE1 expression in sebaceous neoplasms, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) to determine whether the staining patterns may aid in the diagnosis or classification of these neoplasms. TLE1 immunohistochemistry was performed on sebaceous adenoma (n = 26), sebaceoma (n = 10), sebaceous carcinoma (n = 19), BCC (n = 20), and SCC (n = 19). Positivity was defined as dark-brown nuclear staining and graded as 3+ (strong staining of >50% of cells at 4x), 2+ (moderate staining of 10-50% of cells at 4x or >50% of cells staining at 10x), and 1+ (weak staining of