The role of 5-HT receptors in depression.
The role of 5-HT receptors in depression.
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DOI：
10.1186/s13041-017-0306-y
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发表时间：
2017-06-24
期刊：
影响因子：
3.6
通讯作者：
Samuels BA
中科院分区：
文献类型：
--
作者：
Yohn CN;Gergues MM;Samuels BA
抑郁症是一种多基因和高度复杂的精神疾病，仍然是社会的主要负担。抗抑郁药，如选择性5-羟色胺再摄取抑制剂（SSRIs），是世界上最常用的处方药。在这篇综述中，我们将讨论的证据表明，联系血清素和血清素受体的抑郁症的病因和机制的抗抑郁治疗的反应。然后，我们将重新审视血清素在过去几十年中提出的三种不同假说中的作用，以解释抑郁症的病理生理学：单胺假说，神经营养假说和神经源性假说。最后，我们将讨论最近对5-羟色胺受体的研究如何涉及特定的神经回路介导抗抑郁反应，重点放在海马体上。
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology of depression: the monoamine, neurotrophic, and neurogenic hypotheses. Finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus.