Leptin levels and luteinizing hormone pulsatility in normal cycling women and their relationship to daily changes in metabolic rate
Leptin levels and luteinizing hormone pulsatility in normal cycling women and their relationship to daily changes in metabolic rate
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DOI：
10.1016/j.fertnstert.2007.07.1350
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发表时间：
2008-10-01
影响因子：
6.7
通讯作者：
Warren, Michelle R.
中科院分区：
文献类型：
--
作者：
Fenichel, Rebecca M.;Dominguez, Jennifer E.;Warren, Michelle R.
目的：为了确定是否瘦素和LH分泌在正常women.Setting的变化相关的代谢率：学术医学中心。患者（s）和设计：10名年轻女性正常体重和月经进行了研究，在卵泡早期阶段。在24小时内，每15分钟采集一次瘦素和LH水平。代谢率经常使用间接量热法采样。黄体生成素脉动性分析使用聚类程序analysis.Intervention（S）：无。主要结果测量（S）：瘦素，LH和代谢率levels. Results（S）：所有受试者表现出一个昼夜瘦素曲线。黄体生成素脉冲幅度增加，瘦素峰值后变慢。在瘦素峰值后，每6小时LH脉冲的平均（+/- SE）数量从4.30 +/- 0.42减慢到3.00 +/- 0.42脉冲，而脉冲幅度从1.64 +/- 0.26增加到2.51 +/- 0.42 mIU/mL。LH脉冲间期在瘦素峰值后从85.1 ± 3.64分钟增加到108.8 ± 10.26分钟。在瘦素水平达到峰值前约4-6小时，代谢率开始下降，从1.66 +/- 0.24到1.15 +/- 0.04 kcal/min，瘦素达到峰值后，结论：瘦素峰值的时间，夜间LH脉冲的减缓和代谢率的下降之间存在显着的关联，表明正常个体的代谢周期。
Objective: To determine whether leptin and LH secretion in normal women is related to changes in metabolic rate.Setting: Academic medical center.Patient(s) and Design: Ten young women with normal weight and menses were studied during the early follicular phase. Leptin and LH levels were sampled every 15 minutes over a 24-hour period. Metabolic rate was frequently sampled using indirect calorimetry. Luteinizing hormone pulsatility was analyzed using a Cluster Program analysis.Intervention(s): None.Main Outcome Measure(s): Leptin, LH, and metabolic rate levels.Result(s): All subjects demonstrated a diurnal leptin curve. Luteinizing hormone pulses were increased in amplitude and slower after the leptin peak. The average (+/- SE) number of LH pulses per 6 hours slowed from 4.30 +/- 0.42 to 3.00 +/- 0.42 pulses after the leptin peak, whereas pulse amplitude increased from 1.64 +/- 0.26 to 2.51 +/- 0.42 mIU/mL after the leptin peak. The LH interpulse interval increased from 85.1 +/- 3.64 minutes to 108.8 +/- 10.26 minutes after the leptin peak. Metabolic rate began to drop approximately 4-6 hours before leptin levels peaked, going from 1.66 +/- 0.24 to 1.15 +/- 0.04 kcal/min after the leptin peak.Conclusion(s): There is a significant association between the timing of the leptin peak, the nightly slowing of LH pulses, and the fall in metabolic rate, suggesting a metabolic cycle in normal individuals.