The estimation of the number of mutationally silent loci in saturation-mapping experiments.
The estimation of the number of mutationally silent loci in saturation-mapping experiments.
复制标题
饱和作图实验中突变沉默基因座数量的估计。
DOI：
10.1017/s0016672300013914
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
John A. Barrett
中科院分区：
文献类型：
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作者：
John A. Barrett
当采用饱和作图技术来估计不同染色体区域中的基因座数量时，总是存在某些基因座无法检测到的可能性。如果每个基因座的突变体数量遵循泊松分布，则可以估计突变沉默基因座的数量。本文介绍了一种方法，用于拟合这样的数据的泊松分布截断在零级和突变沉默位点的数量估计的方法。这些方法的使用证明了他们的应用程序的一些已发表的数据。
When the technique of saturation mapping is employed to estimate the number of loci in a distinct chromosomal region, there is always the possibility that some loci will not be detected. If the number of mutants per locus follows a Poisson distribution, the number of mutationally silent loci can be estimated. This paper describes a method for fitting such data to a Poisson distribution truncated at the zero class and a method for estimating the number of mutationally silent loci. The use of these methods is demonstrated by their application to some published data.