Androgen biosynthetic pathways in the human prostate
Androgen biosynthetic pathways in the human prostate
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DOI：
10.1016/j.beem.2008.01.008
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发表时间：
2008-04-01
影响因子：
7.4
通讯作者：
Labrie, Fernand
中科院分区：
文献类型：
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作者：
Luu-The, Van;Belanger, Alain;Labrie, Fernand
众所周知，有两种雄激素，即睾酮(T)和双氢睾酮（DHT）；T在睾丸和肌肉中发挥重要作用，DHT对前列腺的发育、功能和病理至关重要。一般认为DHT是由循环T的5 α还原产生的，然后被3 α -羟基类固醇脱氢酶（3 α - hsd）灭活，将DHT转化为5 α -雄烷-3 α， 17 β -二醇（3 α -二醇）。然而，前列腺中各种类固醇生成酶的存在以及各种类固醇前体如脱氢表雄酮硫酸盐（DHEAS），脱氢表雄酮（DHEA）和4-雄烯二酮（4-dione）的高水平的可用性强烈表明存在其他途径参与DHT的生物合成和代谢。大鼠和小鼠的前列腺组织，以及原代细胞和前列腺癌细胞系，提供了一个有点令人困惑的画面。在本章中，我们回顾了这些数据，以提供一个更清晰的途径参与DHT的生物合成和代谢在人类前列腺。
It is well recognized that there are two androgens, namely testosterone (T) and dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is crucial for the development, function and pathology of the prostate. It is generally thought that DHT is produced from the 5 alpha-reduction of circulating T before being inactivated by 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) that converts DHT into 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). However, the presence of various steroidogenic enzymes in the prostate as well as the availability at high levels of various steroid precursors such as dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA) and 4-androstenedione (4-dione) strongly suggest the existence of additional pathways involved in the biosynthesis and metabolism of DHT Because steroidogenesis could be different in different species, data from the literature obtained from various human, dog, rat and mouse prostate tissues, as well as primary cells and prostatic cancer cell lines, provide a somewhat confusing picture. In the present chapter, we review the data in order to provide a clearer picture of the pathways involved in DHT biosynthesis and metabolism in the human prostate.