Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition
Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition
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DOI：
10.1016/j.tetlet.2010.01.052
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发表时间：
2010-03-24
影响因子：
1.8
通讯作者：
Banerjee, Sukdeb
中科院分区：
文献类型：
--
作者：
Hazra, Abhijit;Paira, Priyankar;Banerjee, Sukdeb
A facile synthesis of novel di-spiro compounds has been achieved via 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to the conjugated double bond of andrographolide. When the amino acid was changed from sarcosine to L-proline, the product formation took a different course as determined by 2D NMR and X-ray crystallographic analysis. (C) 2010 Elsevier Ltd. All rights reserved.
