Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas -: Effect of contrast medium extravasation
Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas -: Effect of contrast medium extravasation
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DOI：
10.1034/j.1600-0455.2002.430402.x
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发表时间：
2002-07-01
期刊：
影响因子：
1.3
通讯作者：
Knopp, MV
中科院分区：
文献类型：
--
作者：
Essig, M;Wenz, F;Knopp, MV
目的：探讨不同对比剂渗出程度对不同DSC EPI序列灌注成像的影响。材料与方法：对60例脑胶质瘤患者行FID EPI和SE EPI DSC序列检查。对获得的图像进行定性和定量的评估。对于定性评价，评价了信号时间曲线的均匀性、图像伪影、信号下降程度和增强程度。结果：与SE EPI序列相比，FID EPI序列的信号时间曲线更为均匀，敏感性效应更明显。由于敏感性较低，SE EPI序列对造影剂外渗不敏感。所有患者的信号均恢复到基线水平。在有强强化病变的患者中，FID EPI序列存在相当大的T1效应，这给灌注数据的量化带来了问题。结论：对于无强强化病变的患者，如缺血或血脑屏障完整的肿瘤，FID EPI序列是首选的灌注成像序列。对于疑似强强化病变的患者，应使用SE EPI序列。
Purpose: To assess the influence of the degree of contrast medium extravasation on different DSC EPI MR sequences for perfusion MR imaging.Material and Methods: 60 patients with cerebral gliomas were examined by either an FID EPI or an SE EPI DSC MR sequence. The acquired images were evaluated on a qualitative and quantitative basis. For qualitative assessment, the homogeneity of the signal time curve, image artifacts, the degree of signal drop and the degree of enhancement were evaluated. The quantitative assessment included the percentage of signal drop and the contrast-to-noise ratio of the different EPI sequences was analyzed.Results: FID EPI presented a more homogeneous signal time curve and a more pronounced susceptibility effect than the SE EPI sequence. Due to the lesser susceptibility effect, the SE EPI sequence was not as sensitive to contrast media extravasation. The signal returned to baseline in all patients. In patients with strongly enhancing lesions, the FID EPI sequence suffered from considerable T1 effects, causing problems in the quantification of perfusion data.Conclusion: FID EPI sequences were preferred for perfusion MR imaging in patients without strong enhancing lesions, e.g. in ischemia or tumors with intact blood-brain barrier. In patients with suspected strong enhancing lesions, an SE EPI sequence should be used.