Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study
Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study
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DOI：
10.1016/j.neurobiolaging.2018.03.003
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发表时间：
2018-07-01
影响因子：
4.2
通讯作者：
Xu, Weili
中科院分区：
文献类型：
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作者：
Dintica, Christina S.;Rizzuto, Debora;Xu, Weili
牙齿脱落与认知障碍有关；然而，它与人类大脑结构差异的关系尚不清楚。年龄为60岁的无痴呆参与者（n = 2715）随访长达9年。一个子样本（n = 394）在基线时接受了磁共振成像。在基线时收集牙齿脱落的信息，并在基线和随访时使用简易精神状态检查评估认知功能。采用线性混合效应模型和线性回归模型对数据进行分析。在基线时，404（14.9%）名参与者有部分牙齿脱落，206（7.6%）名参与者有完全牙齿脱落。牙齿脱落与认知能力急剧下降显著相关（β值：-0.18,95%可信区间[CI]: -0.24至-0.11），并且在调整或分层潜在混杂因素后仍然显著。在横断面分析中，完全或部分牙齿脱落的人的总脑容量（β值：-28.89,95% CI: -49.33至-8.45）和灰质体积（β值：-22.60,95% CI: -38.26至-6.94）显著降低。因此，牙齿脱落可能是加速认知衰老的一个危险因素。(C) 2018爱思唯尔公司版权所有。
Tooth loss has been related to cognitive impairment; however, its relation to structural brain differences in humans is unknown. Dementia-free participants (n = 2715) of age >= 60 years were followed up for up to 9 years. A subsample (n = 394) underwent magnetic resonance imaging at baseline. Information on tooth loss was collected at baseline, and cognitive function was assessed using the Mini-Mental State Examination at baseline and at follow-ups. Data were analyzed using linear mixed effects models and linear regression models. At baseline, 404 (14.9%) participants had partial tooth loss, and 206 (7.6%) had complete tooth loss. Tooth loss was significantly associated with a steeper cognitive decline (beta: -0.18, 95% confidence interval [CI]: -0.24 to -0.11) and remained significant after adjusting for or stratifying by potential confounders. In cross-sectional analyses, persons with complete or partial tooth loss had significantly lower total brain volume (beta: -28.89, 95% CI: -49.33 to -8.45) and gray matter volume (beta: -22.60, 95% CI: -38.26 to -6.94). Thus, tooth loss may be a risk factor for accelerated cognitive aging. (C) 2018 Elsevier Inc. All rights reserved.